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Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

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Title: Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Authors: Shirai T; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Nakai A; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Ando E; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Fujimoto J; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Leach S; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Arimori T; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan., Higo D; Thermo Fisher Scientific K.K., Yokohama, Kanagawa, Japan., van Eerden FJ; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Tulyeu J; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Liu YC; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Okuzaki D; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Murayama MA; Department of Animal Models for Human Diseases, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan., Miyata H; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Nunomura K; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Lin B; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Tani A; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan., Ikawa M; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Wing JB; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Standley DM; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Takagi J; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan., Suzuki K; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.
Source: Science immunology [Sci Immunol] 2023 Mar 31; Vol. 8 (81), pp. eadc9324. Date of Electronic Publication: 2023 Mar 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Shirai+T%22">Shirai T</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakai+A%22">Nakai A</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+E%22">Ando E</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Fujimoto+J%22">Fujimoto J</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Leach+S%22">Leach S</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Arimori+T%22">Arimori T</searchLink>; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Higo+D%22">Higo D</searchLink>; Thermo Fisher Scientific K.K., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22van+Eerden+FJ%22">van Eerden FJ</searchLink>; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tulyeu+J%22">Tulyeu J</searchLink>; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Liu+YC%22">Liu YC</searchLink>; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Okuzaki+D%22">Okuzaki D</searchLink>; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Murayama+MA%22">Murayama MA</searchLink>; Department of Animal Models for Human Diseases, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miyata+H%22">Miyata H</searchLink>; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nunomura+K%22">Nunomura K</searchLink>; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Lin+B%22">Lin B</searchLink>; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tani+A%22">Tani A</searchLink>; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kumanogoh+A%22">Kumanogoh A</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ikawa+M%22">Ikawa M</searchLink>; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Wing+JB%22">Wing JB</searchLink>; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Standley+DM%22">Standley DM</searchLink>; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takagi+J%22">Takagi J</searchLink>; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2023 Mar 31; Vol. 8 (81), pp. eadc9324. <i>Date of Electronic Publication: </i>2023 Mar 31.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101688624 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2470-9468 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224709468%22">24709468 </searchLink><i>NLM ISO Abbreviation: </i>Sci Immunol <i>Subsets: </i>MEDLINE
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