Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1.

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Title: Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1.
Authors: Fiskus W; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mill CP; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Birdwell C; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davis JA; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Das K; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Boettcher S; University of Zurich and University Hospital Zurich, CH-8091, Zurich, Switzerland., Kadia TM; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., DiNardo CD; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takahashi K; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Loghavi S; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Soth MJ; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heffernan T; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McGeehan GM; Syndax Pharmaceuticals, Waltham, MA, USA., Ruan X; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Su X; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vakoc CR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA., Daver N; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bhalla KN; The University of Texas MD Anderson Cancer Center, Houston, TX, USA. kbhalla@mdanderson.org.
Source: Blood cancer journal [Blood Cancer J] 2023 Apr 13; Vol. 13 (1), pp. 53. Date of Electronic Publication: 2023 Apr 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2044-5385
DOI:10.1038/s41408-023-00826-6