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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.

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Title: Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Authors: Crawford JJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: crawford.james@gene.com., Feng J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Brightbill HD; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Johnson AR; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wright M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kolesnikov A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Lee W; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Castanedo GM; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Do S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Blaquiere N; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Staben ST; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Chiang PC; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Fan PW; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Baumgardner M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wong S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Godemann R; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Grabbe A; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Wiegel C; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Sujatha-Bhaskar S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hymowitz SG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Liau N; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hsu PL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., McEwan PA; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Ismaili MHA; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Landry ML; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jun 01; Vol. 89, pp. 129277. Date of Electronic Publication: 2023 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Crawford+JJ%22">Crawford JJ</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: crawford.james@gene.com.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Brightbill+HD%22">Brightbill HD</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+AR%22">Johnson AR</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Wright+M%22">Wright M</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Kolesnikov+A%22">Kolesnikov A</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Lee+W%22">Lee W</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Castanedo+GM%22">Castanedo GM</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Do+S%22">Do S</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Blaquiere+N%22">Blaquiere N</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Staben+ST%22">Staben ST</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Chiang+PC%22">Chiang PC</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Fan+PW%22">Fan PW</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Baumgardner+M%22">Baumgardner M</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Wong+S%22">Wong S</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Godemann+R%22">Godemann R</searchLink>; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.<br /><searchLink fieldCode="AU" term="%22Grabbe+A%22">Grabbe A</searchLink>; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.<br /><searchLink fieldCode="AU" term="%22Wiegel+C%22">Wiegel C</searchLink>; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.<br /><searchLink fieldCode="AU" term="%22Sujatha-Bhaskar+S%22">Sujatha-Bhaskar S</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Hymowitz+SG%22">Hymowitz SG</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Liau+N%22">Liau N</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Hsu+PL%22">Hsu PL</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22McEwan+PA%22">McEwan PA</searchLink>; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.<br /><searchLink fieldCode="AU" term="%22Ismaili+MHA%22">Ismaili MHA</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.<br /><searchLink fieldCode="AU" term="%22Landry+ML%22">Landry ML</searchLink>; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
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