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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

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Title: A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Authors: Gong GQ; Cell Signalling, Cancer Institute, University College London, London, UK., Bilanges B; Cell Signalling, Cancer Institute, University College London, London, UK., Allsop B; Drug Discovery Group, Translational Research Office, University College London, London, UK., Masson GR; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., Roberton V; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Askwith T; Drug Discovery Group, Translational Research Office, University College London, London, UK., Oxenford S; Drug Discovery Group, Translational Research Office, University College London, London, UK., Madsen RR; Cell Signalling, Cancer Institute, University College London, London, UK., Conduit SE; Cell Signalling, Cancer Institute, University College London, London, UK., Bellini D; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Fitzek M; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK., Collier M; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK., Najam O; The Hatter Cardiovascular Institute, University College London, London, UK., He Z; The Hatter Cardiovascular Institute, University College London, London, UK., Wahab B; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK., McLaughlin SH; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Chan AWE; Wolfson Institute for Biomedical Research, University College London, London, UK., Feierberg I; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Waltham, MA, USA., Madin A; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Morelli D; Cell Signalling, Cancer Institute, University College London, London, UK., Bhamra A; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK., Vinciauskaite V; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., Anderson KE; Signalling Programme, Babraham Institute, Cambridge, UK., Surinova S; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK., Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, London, UK., Lopez-Guadamillas E; Cell Signalling, Cancer Institute, University College London, London, UK., Wilcox M; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Hooper A; Drug Discovery Group, Translational Research Office, University College London, London, UK., Patel C; Drug Discovery Group, Translational Research Office, University College London, London, UK., Whitehead MA; Cell Signalling, Cancer Institute, University College London, London, UK., Bunney TD; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK., Stephens LR; Signalling Programme, Babraham Institute, Cambridge, UK., Hawkins PT; Signalling Programme, Babraham Institute, Cambridge, UK., Katan M; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK., Yellon DM; The Hatter Cardiovascular Institute, University College London, London, UK., Davidson SM; The Hatter Cardiovascular Institute, University College London, London, UK., Smith DM; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Phillips JB; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Angell R; Drug Discovery Group, Translational Research Office, University College London, London, UK.; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK., Williams RL; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Vanhaesebroeck B; Cell Signalling, Cancer Institute, University College London, London, UK. bart.vanh@ucl.ac.uk.
Source: Nature [Nature] 2023 Jun; Vol. 618 (7963), pp. 159-168. Date of Electronic Publication: 2023 May 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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