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Real-world effectiveness of pembrolizumab as first-line therapy for cisplatin-ineligible patients with advanced urothelial carcinoma: the ARON-2 study.

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Title: Real-world effectiveness of pembrolizumab as first-line therapy for cisplatin-ineligible patients with advanced urothelial carcinoma: the ARON-2 study.
Authors: Santoni M; Oncology Unit, Macerata Hospital, Via Santa Lucia 2, 62100, Macerata, Italy. mattymo@alice.it., Myint ZW; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0293, USA., Büttner T; Department of Urology, University Hospital Bonn (UKB), 53127, Bonn, Germany., Takeshita H; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan., Okada Y; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan., Lam ET; University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA., Gilbert D; University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA., Küronya Z; Department of Genitourinary Medical Oncology and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary., Tural D; Department of Medical Oncology, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Zuhuratbaba District, Tevfik Saglam St. No: 11, Bakirkoy, Istanbul, Turkey., Pichler R; Department of Urology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria., Grande E; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain., Crabb SJ; Southampton Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Kemp R; Southampton Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Massari F; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni - 15, Bologna, Italy., Scagliarini S; UOC di Oncologia, Azienda Ospedaliera di Rilievo Nazionale Cardarelli di Napoli, Naples, Italy., Iacovelli R; Oncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Vau N; Urologic Oncology, Champalimaud Clinical Center, 1400-038, Lisbon, Portugal., Basso U; Medical Oncology 1 Unit, Department of Oncology, Istituto Oncologico Veneto IOV IRCCS, 35128, Padua, Italy., Maruzzo M; Medical Oncology 1 Unit, Department of Oncology, Istituto Oncologico Veneto IOV IRCCS, 35128, Padua, Italy., Molina-Cerrillo J; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain., Galli L; Oncology Unit 2, University Hospital of Pisa, 56126, Pisa, Italy., Bamias A; 2nd Propaedeutic Department of Internal Medicine, School of Medicine, ATTIKON University Hospital, National and Kapodistrian University of Athens, Athens, Greece., De Giorgi U; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Zucali PA; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Department of Oncology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Rizzo M; Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Piazza G. Cesare 11, 70124, Bari, Italy., Seront E; Department of Medical Oncology, Centre Hospitalier de Jolimont, Haine Saint Paul, Belgium., Popovic L; Oncology Institute of Vojvodina, Faculty of Medicine, University Novi Sad, Novi Sad, Serbia., Caffo O; Medical Oncology Unit, Santa Chiara Hospital, Trento, Italy., Buti S; Medical Oncology Unit, Department of Medicine and Surgery, University Hospital of Parma, University of Parma, Parma, Italy., Kanesvaran R; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Kopecky J; Department of Clinical Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Kucharz J; Department of Uro-Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Zeppellini A; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Fiala O; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic., Landmesser J; Klinik für Urologie, Ratzeburger Allee 160, 23538, Lübeck, Germany., Ansari J; Medical Oncology, Tawam Hospital, Al Ain, United Arab Emirates., Giannatempo P; Dipartimento di Oncologia Medica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Rizzo A; Struttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico 'Don Tonino Bello', I.R.C.C.S. Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Zabalza IO; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain., Monteiro FSM; Latin American Cooperative Oncology Group - LACOG, Porto Alegre, Brazil.; Oncology and Hematology Department, Hospital Santa Lucia, SHLS 716 Cj. C, Brasília, DF, 70390-700, Brazil., Battelli N; Oncology Unit, Macerata Hospital, Via Santa Lucia 2, 62100, Macerata, Italy., Calabrò F; Department of Oncology, San Camillo Forlanini Hospital, Rome, Italy., Porta C; Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Piazza G. Cesare 11, 70124, Bari, Italy.; Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2023 Sep; Vol. 72 (9), pp. 2961-2970. Date of Electronic Publication: 2023 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Real-world effectiveness of pembrolizumab as first-line therapy for cisplatin-ineligible patients with advanced urothelial carcinoma: the ARON-2 study.
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  Data: <searchLink fieldCode="AU" term="%22Santoni+M%22">Santoni M</searchLink>; Oncology Unit, Macerata Hospital, Via Santa Lucia 2, 62100, Macerata, Italy. mattymo@alice.it.<br /><searchLink fieldCode="AU" term="%22Myint+ZW%22">Myint ZW</searchLink>; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0293, USA.<br /><searchLink fieldCode="AU" term="%22Büttner+T%22">Büttner T</searchLink>; Department of Urology, University Hospital Bonn (UKB), 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Takeshita+H%22">Takeshita H</searchLink>; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+Y%22">Okada Y</searchLink>; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Lam+ET%22">Lam ET</searchLink>; University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+D%22">Gilbert D</searchLink>; University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Küronya+Z%22">Küronya Z</searchLink>; Department of Genitourinary Medical Oncology and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Tural+D%22">Tural D</searchLink>; Department of Medical Oncology, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Zuhuratbaba District, Tevfik Saglam St. No: 11, Bakirkoy, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Pichler+R%22">Pichler R</searchLink>; Department of Urology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Grande+E%22">Grande E</searchLink>; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Crabb+SJ%22">Crabb SJ</searchLink>; Southampton Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Kemp+R%22">Kemp R</searchLink>; Southampton Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Massari+F%22">Massari F</searchLink>; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni - 15, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Scagliarini+S%22">Scagliarini S</searchLink>; UOC di Oncologia, Azienda Ospedaliera di Rilievo Nazionale Cardarelli di Napoli, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Iacovelli+R%22">Iacovelli R</searchLink>; Oncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vau+N%22">Vau N</searchLink>; Urologic Oncology, Champalimaud Clinical Center, 1400-038, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Basso+U%22">Basso U</searchLink>; Medical Oncology 1 Unit, Department of Oncology, Istituto Oncologico Veneto IOV IRCCS, 35128, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Maruzzo+M%22">Maruzzo M</searchLink>; Medical Oncology 1 Unit, Department of Oncology, Istituto Oncologico Veneto IOV IRCCS, 35128, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Molina-Cerrillo+J%22">Molina-Cerrillo J</searchLink>; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Galli+L%22">Galli L</searchLink>; Oncology Unit 2, University Hospital of Pisa, 56126, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Bamias+A%22">Bamias A</searchLink>; 2nd Propaedeutic Department of Internal Medicine, School of Medicine, ATTIKON University Hospital, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22De+Giorgi+U%22">De Giorgi U</searchLink>; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Zucali+PA%22">Zucali PA</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Department of Oncology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+M%22">Rizzo M</searchLink>; Division of Medical Oncology, A.O.U. 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Cesare 11, 70124, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Seront+E%22">Seront E</searchLink>; Department of Medical Oncology, Centre Hospitalier de Jolimont, Haine Saint Paul, Belgium.<br /><searchLink fieldCode="AU" term="%22Popovic+L%22">Popovic L</searchLink>; Oncology Institute of Vojvodina, Faculty of Medicine, University Novi Sad, Novi Sad, Serbia.<br /><searchLink fieldCode="AU" term="%22Caffo+O%22">Caffo O</searchLink>; Medical Oncology Unit, Santa Chiara Hospital, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Buti+S%22">Buti S</searchLink>; Medical Oncology Unit, Department of Medicine and Surgery, University Hospital of Parma, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Kanesvaran+R%22">Kanesvaran R</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kopecky+J%22">Kopecky J</searchLink>; Department of Clinical Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kucharz+J%22">Kucharz J</searchLink>; Department of Uro-Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Zeppellini+A%22">Zeppellini A</searchLink>; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fiala+O%22">Fiala O</searchLink>; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Landmesser+J%22">Landmesser J</searchLink>; Klinik für Urologie, Ratzeburger Allee 160, 23538, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ansari+J%22">Ansari J</searchLink>; Medical Oncology, Tawam Hospital, Al Ain, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Giannatempo+P%22">Giannatempo P</searchLink>; Dipartimento di Oncologia Medica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+A%22">Rizzo A</searchLink>; Struttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico 'Don Tonino Bello', I.R.C.C.S. 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Cesare 11, 70124, Bari, Italy.; Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy.
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