Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.
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| Title: | Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases. |
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| Authors: | Zorn K; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden., Back CR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Barringer R; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Chadimová V; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden., Manzo-Ruiz M; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Mbatha SZ; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK., Mobarec JC; Mechanistic and Structural Biology, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK., Williams SE; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., van der Kamp MW; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Race PR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Willis CL; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK., Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden. |
| Source: | Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Jul 17; Vol. 24 (14), pp. e202300382. Date of Electronic Publication: 2023 Jun 18. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1439-7633 |
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| DOI: | 10.1002/cbic.202300382 |
