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Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.

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Title: Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.
Authors: Zorn K; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden., Back CR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Barringer R; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Chadimová V; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden., Manzo-Ruiz M; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Mbatha SZ; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK., Mobarec JC; Mechanistic and Structural Biology, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK., Williams SE; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., van der Kamp MW; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Race PR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Willis CL; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK., Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.
Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Jul 17; Vol. 24 (14), pp. e202300382. Date of Electronic Publication: 2023 Jun 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.
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  Data: <searchLink fieldCode="AU" term="%22Zorn+K%22">Zorn K</searchLink>; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Back+CR%22">Back CR</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Barringer+R%22">Barringer R</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Chadimová+V%22">Chadimová V</searchLink>; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Manzo-Ruiz+M%22">Manzo-Ruiz M</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Mbatha+SZ%22">Mbatha SZ</searchLink>; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Mobarec+JC%22">Mobarec JC</searchLink>; Mechanistic and Structural Biology, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.<br /><searchLink fieldCode="AU" term="%22Williams+SE%22">Williams SE</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Kamp+MW%22">van der Kamp MW</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Race+PR%22">Race PR</searchLink>; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Willis+CL%22">Willis CL</searchLink>; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Hayes+MA%22">Hayes MA</searchLink>; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22100937360%22">Chembiochem : a European journal of chemical biology</searchLink> [Chembiochem] 2023 Jul 17; Vol. 24 (14), pp. e202300382. <i>Date of Electronic Publication: </i>2023 Jun 18.
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