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Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade.

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Title: Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade.
Authors: Yam-Puc JC; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK. jcy28@cam.ac.uk., Hosseini Z; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Horner EC; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Gerber PP; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Beristain-Covarrubias N; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Hughes R; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Lulla A; Department of Biochemistry, University of Cambridge, Cambridge, UK., Rust M; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Boston R; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Ali M; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Fischer K; Department of Biochemistry, University of Cambridge, Cambridge, UK., Simmons-Rosello E; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., O'Reilly M; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Robson H; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Booth LH; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Kahanawita L; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Correa-Noguera A; Department of Oncology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Favara D; Department of Oncology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Ceron-Gutierrez L; Department of Clinical Immunology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Keller B; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Craxton A; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Anderson GSF; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Sun XM; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Elmer A; NIHR Cambridge Clinical Research Facility, Cambridge, UK., Saunders C; NIHR Cambridge Clinical Research Facility, Cambridge, UK., Bermperi A; NIHR Cambridge Clinical Research Facility, Cambridge, UK., Jose S; NIHR Cambridge Clinical Research Facility, Cambridge, UK., Kingston N; NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Mulroney TE; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Piñon LPG; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Chapman MA; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Grigoriadou S; Department of Clinical Immunology, Barts Health, London, UK., MacFarlane M; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Willis AE; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Patil KR; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Spencer S; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK., Staples E; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK.; Department of Clinical Immunology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Warnatz K; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Immunology, University Hospital Zurich, Zurich, Switzerland., Buckland MS; Department of Clinical Immunology, Barts Health, London, UK.; UCL GOSH Institute of Child Health Division of Infection and Immunity, Section of Cellular and Molecular Immunology, London, UK., Hollfelder F; Department of Biochemistry, University of Cambridge, Cambridge, UK., Hyvönen M; Department of Biochemistry, University of Cambridge, Cambridge, UK., Döffinger R; Department of Clinical Immunology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Parkinson C; Department of Oncology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Lear S; Department of Clinical Immunology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Thaventhiran JED; Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK. jedt2@cam.ac.uk.; Department of Clinical Immunology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, UK. jedt2@cam.ac.uk.
Corporate Authors: CITIID-NIHR COVID−19 BioResource Collaboration
Source: Nature communications [Nat Commun] 2023 Jun 27; Vol. 14 (1), pp. 3292. Date of Electronic Publication: 2023 Jun 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2041-1723
DOI:10.1038/s41467-023-38810-0