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Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.

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Title: Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.
Authors: Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63108, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA., Norton J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA., Johnson M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA., Fagan A; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA., Bateman RJ; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA., Perrin RJ; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA., Morris JC; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Chhatwal JP; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Schofield PR; Neuroscience Research Australia, Randwick, NSW 2031, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Chui H; Department of Neurology, University of Southern California, Los Angeles, CA 90089, USA., Wang F; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA., Novotny B; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA., Eteleeb A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA., Karch C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA., Schindler SE; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA., Rhinn H; Leal Therapeutics, 17 Briden St., Office 329, Worcester, MA 01605, USA., Johnson ECB; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Oh HS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Rutledge JE; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Dammer EB; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Seyfried NT; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.; Department of Biochemistry, Emory School of Medicine, Atlanta, GA 30329, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Harari O; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Jul 05; Vol. 15 (703), pp. eabq5923. Date of Electronic Publication: 2023 Jul 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abq5923