Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.

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Title: Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.
Authors: Huang Q; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Chen AT; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.; Biological and Biomedical Sciences, Harvard University, Cambridge, Massachusetts, United States of America., Chan KY; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Sorensen H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Barry AJ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Azari B; Electrical & Computer Engineering Department, Northeastern University, Boston, Massachusetts, United States of America., Zheng Q; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Beddow T; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Zhao B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Tobey IG; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Moncada-Reid C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Eid FE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.; Department of Systems and Computer Engineering, Al-Azhar University, Cairo, Egypt., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States of America., Ljungberg MC; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.; Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, United States of America., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States of America., Heaney JD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America., Chan YA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Deverman BE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Source: PLoS biology [PLoS Biol] 2023 Jul 19; Vol. 21 (7), pp. e3002112. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1545-7885
DOI:10.1371/journal.pbio.3002112