Genetic insights into resting heart rate and its role in cardiovascular disease.
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| Title: | Genetic insights into resting heart rate and its role in cardiovascular disease. |
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| Authors: | van de Vegte YJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Eppinga RN; Department of Cardiology, Isala Zwolle ziekenhuis, Zwolle, 8025 AB, the Netherlands., van der Ende MY; Department of Cardiology, University medical Center Utrecht, Utrecht, 3584 Cx, the Netherlands., Hagemeijer YP; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands.; Analytical Biochemistry, University of Groningen, Groningen, 9713 AV, the Netherlands., Mahendran Y; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Salfati E; Department of Medicine, Stanford University School of Medicine, Stanford, 94305, USA.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI48109, USA., Tan VY; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, BS82BN, UK.; MRC Integrative Epidemiology, University of Bristol, Bristol, BS82BN, UK., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21215, USA., Ntalla I; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Appel EV; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Brody JA; Medicine, University of Washington, Seattle, 98195, USA., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, 1015, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Polasek O; Department of Public Health, University of Split School of Medicine, Split, 21000, Croatia.; Algebra LAB, Algebra University College, Zagreb, 10000, Croatia., Sveinbjornsson G; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland., Lecoeur C; UMR 8199, University of Lille Nord de France, Lille, 59000, France., Ladenvall C; Clinial Genomics Uppsala, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, 75185, Sweden.; Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, 20502, Sweden., Zhao JH; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, CB2 0BB, UK., Isaacs A; CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), Department of Physiology, Maastricht University, Maastricht, 6229ER, Netherlands., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108-2212, Campus Box 8506, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Hwang SJ; Division of Intramural Research, National Heart Lung and Blood Institute, NIH, USA, Framingham, 1702, USA., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Auro K; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Bielak LF; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Zeng L; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, 80636, Germany., Shah N; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.; Pharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad, 22060, Pakistan., Nethander M; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530, Sweden., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH16 4UX, UK., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany., Qi L; Department of Epidemiology, Tulane University, New Orleans, LA, 70112, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Rizzi F; Unit of Biomedicine, Bio4Dreams-Business Nursery for Life Sciences, Milano, 20121, Italy., Tanaka T; Longitudinal Study Section, National Institute on Aging, Baltimore, 21224, USA., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Cocca M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Lange L; Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045, USA., Müller-Nurasyid M; IBE, Ludwig-Maximilians-University Munich, LMU Munich, Munich, 81377, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, 55101, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany., Roselli C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, 02142, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, 68163, Germany., Guo X; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Lin HJ; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Pavani F; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Galesloot TE; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., Noordam R; Department of Internal Medicine, section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health, Amsterdam UMC, Amsterdam UMC, Vrije Universiteit, Amsterdam, Amsterdam, 1081 HL, the Netherlands., Schraut KE; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK., den Hoed M; The Beijer laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Uppsala, 75237, Sweden., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, 24105, Germany., Trompet S; Department of Internal Medicine, section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands., van den Berg ME; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, the Netherlands., Pistis G; Institute of Genetics and Biomedic Research (IRGB), Italian National Research Council (CNR), Monserrato, (CA), 9042, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, USA., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany., Sim XS; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore., Li HL; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SL, UK., Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Witte DR; Department of Public Health, Aarhus University, Aarhus C, 8000, Denmark., Iribarren C; Division of Research, Kaiser Permenente of Northern California, Oakland, 94612, USA.; The Scripps Research Institute, La Jolla, 10550, USA., Launer L; National Institute on Aging, Bethesda, MSC2292, USA., Ring SM; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, BS82BN, UK.; MRC Integrative Epidemiology, University of Bristol, Bristol, BS82BN, UK., de Vries PS; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, 77030, USA., Sever P; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, 2400, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA.; Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Psaty BM; Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, 98195, USA., Sotoodehnia N; Medicine and Epidemiology, University of Washington, Seattle, 98195, USA., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, 21000, Croatia.; Algebra LAB, Algebra University College, Zagreb, 10000, Croatia., Arnar DO; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.; Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, 101, Iceland., Gudbjartsson DF; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, 101, Iceland., Holm H; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland., Balkau B; Centre for Research in Epidemiology and Population Health, Institut national de la santé et de la recherche médicale, Villejuif, 94800, France.; UMRS 1018, University Versailles Saint-Quentin-en-Yvelines, Versailles, 78035, France.; UMRS 1018, University Paris Sud, Villejuif, 94807, France., Silva CT; Genetic Epidemiology Unit, Dept. of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000CA, Netherlands., Newton-Cheh CH; Cardiology Section, Massachusetts general hospital,, Boston, 02130, USA., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, FI-33521, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Salo P; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Peyser PA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Schunkert H; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, 80636, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, 80636, Germany., Lorentzon M; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Region Västra Götaland, Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Mölndal, 43180, Sweden.; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, 3000, Australia., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, 00014, Finland., Rao DC; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Cornelis MC; Preventive Medicine, Northwestern University, Chicago, IL, 60611, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Stolarz-Skrzypek K; Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, 31-008, Poland., Bandinelli S; Geriatric Unit, Unità sanitaria locale Toscana Centro, Florence, 50142, Italy., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Sinagra G; Cardiovascular Department, 'Ospedali Riuniti and University of Trieste', Trieste, 34149, Italy., Meitinger T; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, München, 81675, Germany.; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany., Sinner MF; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Department of Cardiology, University Hospital, LMU Munich, Munich, 81377, Germany., Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, 55101, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, 81377, Germany., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany., Taylor KD; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Yao J; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Foco L; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmo, 221 85, Sweden.; Lund University Diabetes Center, Lund University, Malmö, 221 85, Sweden., de Graaf J; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., de Geus EJC; Biological Psychology, EMGO+ Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University, Amsterdam, 1081 BT, the Netherlands., Johansson Å; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 75108, Sweden., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Uppsala, 75237, Sweden., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, 24105, Germany., Macfarlane PW; Institute of Health and Wellbeing, Faculty of Medicine, University of Glasgow, Glasgow, G12 0XH, UK., Tarasov KV; Laboratory of Cardiovascular Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Tan N; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Felix SB; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany., Tai ES; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Quek DQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Ormel J; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, 75237, Sweden., Lindgren C; Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Morris AP; Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FI-20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FI-20521, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, FI-20521, Finland., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Assimes T; Department of Medicine, Stanford University School of Medicine, Stanford, 94305, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School,, University of Bristol, Bristol, BS8 2BN, UK., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, 77030, USA., Munroe PB; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Biomedical Research Centre, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Loos RJF; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark.; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, 98195, USA., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University hospital, Lausanne, 1015, Switzerland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK., Stefansson K; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland., Froguel P; Department of Metabolism, Imperial College London, London, W12 0HS, UK.; Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, Lille University Hospital, EGID, Lille, 59000, France.; University of Lille, Lille, 59000, France., Groop L; Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, 20502, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00290, Finland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., van Duijn CM; Genetic Epidemiology Unit, Dept. of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000CA, Netherlands., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108-2212, Campus Box 8506, USA., O'Donnell CJ; Cardiology Section, VA Boston Healthcare System, Harvard Medical School, Boston, MA, 02132, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, FI-33521, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33521, Finland., Perola M; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Erdmann J; Institute for Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Ohlsson C; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, 41345, Sweden., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Eriksson JG; Department of General practice and primary care, University of Helsinki, Helsinki, 00014, Finland.; Department of Obstetrics and Gynecology, National University of Singapore, Singapore, 119228, Singapore.; Public health Research Program, Folkhalsan Research Center, Helsinki, 000250, Finland., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany.; Centre for Urban Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany., Kraft P; Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02112, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Cusi D; Unit of Biomedicine, Bio4Dreams-Business Nursery for Life Sciences, Milano, 20121, Italy.; Institute of Biomedical Technologies, National Research Council of Italy, Segrate, (MI), 20090, Italy., Ferrucci L; Longitudinal Study Section, National Institute on Aging, Baltimore, 21224, USA., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Girotto G; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, 34149, Italy., Correa A; Jackson Heart Study, University of Mississippi Medical Center, Jackson, 39216, USA., Kääb S; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Department of Cardiology, University Hospital, LMU Munich, Munich, 81377, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, 81377, Germany., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, UK., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, 68161, Germany., Rotter JI; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, 221 85, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, 221 84, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, 413 45, Sweden., Kiemeney LALM; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health, Amsterdam UMC, Amsterdam UMC, Vrije Universiteit, Amsterdam, Amsterdam, 1081 HL, the Netherlands., Gyllensten U; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 75108, Sweden., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK., Burgess S; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Uppsala, 75237, Sweden., Lieb W; Institute of Epidemiology and Biobank PopGen, Kiel University, Kiel, 24105, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands.; Netherlands Heart Institute, Utrecht, 3511 EP, the Netherlands., Eijgelsheim M; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, the Netherlands.; Department of Nephrology, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Lakatta ELM; Laboratory of Cardiovascular Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Dörr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Tsinghua Medicine, Tsinghua University, Beijing, 100084, China., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Riese H; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands. P.vanderHarst@umcutrecht.nl.; Department of Cardiology, University medical Center Utrecht, Utrecht, 3584 Cx, the Netherlands. P.vanderHarst@umcutrecht.nl.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands. P.vanderHarst@umcutrecht.nl. |
| Corporate Authors: | DCCT/EDIC Research Group |
| Source: | Nature communications [Nat Commun] 2023 Aug 02; Vol. 14 (1), pp. 4646. Date of Electronic Publication: 2023 Aug 02. |
| Publication Type: | Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-39521-2 |
