Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.
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| Title: | Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer. |
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| Authors: | Oliveira G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Egloff AM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA., Afeyan AB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Wolff JO; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zeng Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chernock RD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Zhou L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Messier C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Lizotte P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Stromhaug K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Penter L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Hematology, Oncology and Tumor Immunology, Campus Virchow Klinikum, Berlin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Haddad RI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Hanna GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Schoenfeld JD; Department of Radiation-Oncology, Brigham and Women's Hospital, Boston, MA, USA., Goguen LA; Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA., Annino DJ; Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA., Jo V; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Oppelt P; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine/Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA., Pipkorn P; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Jackson R; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Puram SV; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Paniello RC; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Rich JT; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Webb J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zevallos JP; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Mansour M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Fu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dunn GP; Department of Neurological Surgery, Massachusetts General Hospital, Boston, MA, USA., Rodig SJ; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Ley J; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine/Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA., Morris LGT; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dunn L; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Paweletz CP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Kallogjeri D; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Piccirillo JF; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA., Adkins DR; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine/Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA. |
| Source: | Science immunology [Sci Immunol] 2023 Sep 08; Vol. 8 (87), pp. eadf4968. Date of Electronic Publication: 2023 Sep 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adf4968 |
