Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding.
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| Title: | Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding. |
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| Authors: | Van der Veken M; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Brouwers J; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Ozbey AC; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland., Umehara K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland., Stillhart C; Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Knops N; Laboratory for Pediatrics, Department of Development & Regeneration, KU Leuven, O&N3, Bus 817, 3000 Leuven, Belgium.; Department of Pediatrics, Groene Hart Ziekenhuis, 2803 Gouda, The Netherlands., Augustijns P; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Parrott NJ; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland. |
| Source: | Pharmaceutics [Pharmaceutics] 2023 Aug 29; Vol. 15 (9). Date of Electronic Publication: 2023 Aug 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1999-4923 |
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| DOI: | 10.3390/pharmaceutics15092231 |
