Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding.
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| Title: | Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding. |
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| Authors: | Van der Veken M; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Brouwers J; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Ozbey AC; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland., Umehara K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland., Stillhart C; Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Knops N; Laboratory for Pediatrics, Department of Development & Regeneration, KU Leuven, O&N3, Bus 817, 3000 Leuven, Belgium.; Department of Pediatrics, Groene Hart Ziekenhuis, 2803 Gouda, The Netherlands., Augustijns P; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium., Parrott NJ; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland. |
| Source: | Pharmaceutics [Pharmaceutics] 2023 Aug 29; Vol. 15 (9). Date of Electronic Publication: 2023 Aug 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 37765200 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Van+der+Veken+M%22">Van der Veken M</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Brouwers+J%22">Brouwers J</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ozbey+AC%22">Ozbey AC</searchLink>; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Umehara+K%22">Umehara K</searchLink>; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stillhart+C%22">Stillhart C</searchLink>; Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Knops+N%22">Knops N</searchLink>; Laboratory for Pediatrics, Department of Development & Regeneration, KU Leuven, O&N3, Bus 817, 3000 Leuven, Belgium.; Department of Pediatrics, Groene Hart Ziekenhuis, 2803 Gouda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Augustijns+P%22">Augustijns P</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Parrott+NJ%22">Parrott NJ</searchLink>; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, 4070 Basel, Switzerland. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101534003%22">Pharmaceutics</searchLink> [Pharmaceutics] 2023 Aug 29; Vol. 15 (9). <i>Date of Electronic Publication: </i>2023 Aug 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101534003 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1999-4923 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219994923%22">19994923 </searchLink><i>NLM ISO Abbreviation: </i>Pharmaceutics <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=37765200 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/pharmaceutics15092231 Languages: – Code: eng Text: English Titles: – TitleFull: Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Van der Veken M – PersonEntity: Name: NameFull: Brouwers J – PersonEntity: Name: NameFull: Ozbey AC – PersonEntity: Name: NameFull: Umehara K – PersonEntity: Name: NameFull: Stillhart C – PersonEntity: Name: NameFull: Knops N – PersonEntity: Name: NameFull: Augustijns P – PersonEntity: Name: NameFull: Parrott NJ IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 08 Text: 2023 Aug 29 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 1999-4923 Numbering: – Type: volume Value: 15 – Type: issue Value: 9 Titles: – TitleFull: Pharmaceutics Type: main |
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