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Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours.

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Title: Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours.
Authors: Maekawa N; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan., Konnai S; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan., Hosoya K; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Kim S; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Kinoshita R; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Deguchi T; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan., Owaki R; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Tachibana Y; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Yokokawa M; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan., Takeuchi H; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan., Kagawa Y; North Lab, Sapporo, Japan., Takagi S; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Veterinary Surgery 1, School of Veterinary Medicine, Azabu University, Sagamihara, Japan., Ohta H; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan., Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan., Yamamoto S; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan., Yamamoto K; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan., Suzuki Y; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan., Okagawa T; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan., Murata S; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan., Ohashi K; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, International Affairs Office, Hokkaido University, Sapporo, Japan.
Source: PloS one [PLoS One] 2023 Oct 04; Vol. 18 (10), pp. e0291727. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours.
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  Data: <searchLink fieldCode="AU" term="%22Maekawa+N%22">Maekawa N</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Konnai+S%22">Konnai S</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Hosoya+K%22">Hosoya K</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+R%22">Kinoshita R</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Deguchi+T%22">Deguchi T</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.<br /><searchLink fieldCode="AU" term="%22Owaki+R%22">Owaki R</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Tachibana+Y%22">Tachibana Y</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Yokokawa+M%22">Yokokawa M</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+H%22">Takeuchi H</searchLink>; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kagawa+Y%22">Kagawa Y</searchLink>; North Lab, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takagi+S%22">Takagi S</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Veterinary Surgery 1, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Ohta+H%22">Ohta H</searchLink>; Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan.; Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+Y%22">Kato Y</searchLink>; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+Y%22">Suzuki Y</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Okagawa+T%22">Okagawa T</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Murata+S%22">Murata S</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohashi+K%22">Ohashi K</searchLink>; Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan.; Faculty of Veterinary Medicine, International Affairs Office, Hokkaido University, Sapporo, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2023 Oct 04; Vol. 18 (10), pp. e0291727. <i>Date of Electronic Publication: </i>2023 Oct 04 (<i>Print Publication: </i>2023).
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