Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis.

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Title: Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis.
Authors: Rady AM; Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University , Zagazig, Egypt.; Faculty of Biotechnology, October University for Modern Sciences and Arts , Giza, Egypt., El-Sayed ASA; Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University , Zagazig, Egypt., El-Baz AF; Genetic Engineering and Biotechnology Research Institute, University of Sadat City , Sadat City, Egypt., Abdel-Fattah GG; Botany Department, Faculty of Science, Mansoura University , Mansoura, Egypt., Magdeldin S; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt.; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University , Ismailia, Egypt., Ahmed E; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt.; Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University , Ismailia, Egypt., Osama A; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt., Hassanein SE; Agricultural Genetic Engineering Research Institute (AGERI), Agriculture Research Center , Cairo, Egypt., Saed H; Microbiology Department, Faculty of Veterinary Medicine, Zagazig University , Zagazig, Egypt., Yassin M; Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University , Zagazig, Egypt.
Source: Microbiology spectrum [Microbiol Spectr] 2023 Dec 12; Vol. 11 (6), pp. e0228123. Date of Electronic Publication: 2023 Oct 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2165-0497
DOI:10.1128/spectrum.02281-23