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Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.

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Title: Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.
Authors: Derudas M; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom., O'Reilly M; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; Department of Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands., Kirkwood NK; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; School of Biosciences, University of Kent, Canterbury, United Kingdom., Kenyon EJ; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; School of Medicine, Institute of Life Sciences, Swansea University, Swansea, United Kingdom., Grimsey S; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom., Kitcher SR; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; Section on Neuronal Circuitry, National Institute on Deafness and Other Communication Disorders NIH, Bethesda, MD, United States., Workman S; Department of Biosciences, College of Science, Swansea University, Swansea, United Kingdom., Bull JC; Department of Biosciences, College of Science, Swansea University, Swansea, United Kingdom., Ward SE; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; Medicines Discovery Institute, Cardiff University, Cardiff, United Kingdom., Kros CJ; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom., Richardson GP; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Source: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 10; Vol. 11, pp. 1247324. Date of Electronic Publication: 2023 Oct 10 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2296-634X
DOI:10.3389/fcell.2023.1247324