A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition.

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Bibliographic Details
Title: A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition.
Authors: Gao CW; Department of Genetic Medicine.; Department of Molecular Biology and Genetics, and., Lin W; Department of Genetic Medicine., Riddle RC; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Research and Development Service, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA., Kushwaha P; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Boukas L; Department of Genetic Medicine.; Department of Biostatistics, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA., Björnsson HT; Department of Genetic Medicine.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Landspítali University Hospital, Reykjavík, Iceland., Hansen KD; Department of Genetic Medicine.; Department of Biostatistics, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Fahrner JA; Department of Genetic Medicine.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Source: JCI insight [JCI Insight] 2024 Jan 09; Vol. 9 (1). Date of Electronic Publication: 2024 Jan 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.173392