OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.

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Title: OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.
Authors: Purvis GSD; Sir William Dunn School of Pathology, University of Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK., Collino M; Dept of Neurosciences 'Rita Levi Montalcini' University of Turin, Turin, IT., van Dam AD; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Einaudi G; Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy., Ng Y; Division of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Shanmuganathan M; Division of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Patel SY; Primary Immunodeficiency Unit, Department of Experimental Medicine, Nuffield Department of Medicine, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, UK., Thiemermann C; The William Harvey Research Institute, Queen Mary University of London, London, UK., Channon KM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Greaves DR; Sir William Dunn School of Pathology, University of Oxford, UK.
Corporate Authors: Oxford Acute Myocardial Infarction (OxAMI) Study
Source: Diabetes [Diabetes] 2024 Jan 08. Date of Electronic Publication: 2024 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1939-327X
DOI:10.2337/db22-0275