Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.
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| Title: | Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression. |
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| Authors: | Ladha KS; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Lee J; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Mattina GF; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Pazmino-Canizares J; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Wijeysundera DN; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Gholamali Nezhad F; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Philip K; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Tassone VK; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Adamsahib F; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Bhat V; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Neuroscience Research Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. |
| Corporate Authors: | SMILE Study Investigators |
| Source: | PloS one [PLoS One] 2024 Jan 19; Vol. 19 (1), pp. e0297330. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024). |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0297330 |
