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Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.

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Title: Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.
Authors: Ladha KS; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Lee J; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Mattina GF; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Pazmino-Canizares J; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Wijeysundera DN; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada., Gholamali Nezhad F; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Philip K; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Tassone VK; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Adamsahib F; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada., Bhat V; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Neuroscience Research Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Corporate Authors: SMILE Study Investigators
Source: PloS one [PLoS One] 2024 Jan 19; Vol. 19 (1), pp. e0297330. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024).
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.
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  Data: <searchLink fieldCode="AU" term="%22Ladha+KS%22">Ladha KS</searchLink>; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mattina+GF%22">Mattina GF</searchLink>; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pazmino-Canizares+J%22">Pazmino-Canizares J</searchLink>; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wijeysundera+DN%22">Wijeysundera DN</searchLink>; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gholamali+Nezhad+F%22">Gholamali Nezhad F</searchLink>; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Philip+K%22">Philip K</searchLink>; Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tassone+VK%22">Tassone VK</searchLink>; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Adamsahib+F%22">Adamsahib F</searchLink>; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bhat+V%22">Bhat V</searchLink>; Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Neuroscience Research Program, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="CA" term="%22SMILE+Study+Investigators%22">SMILE Study Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2024 Jan 19; Vol. 19 (1), pp. e0297330. <i>Date of Electronic Publication: </i>2024 Jan 19 (<i>Print Publication: </i>2024).
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              Text: 2024 Jan 19
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