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A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs.

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Title: A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs.
Authors: Wang C; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. c.wang@dkfz.de.; Faculty of Medicine, Heidelberg University, Im Neuenheimer Feld 672, 69120, Heidelberg, Germany. c.wang@dkfz.de.; Department of Thyroid Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China. c.wang@dkfz.de., Sun M; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China., Shao C; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Zhuo Y; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany., Harim Y; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany., Peng T; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China., Tian W; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Stöffler N; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Schneider M; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Helm D; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Chu Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China., Fu B; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China., Jin X; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 200025, Shanghai, China., Mallm JP; Single-cell Open Lab, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Mall M; Cell Fate Engineering and Disease Modeling Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; HITBR Hector Institute for Translational Brain Research gGmbH, 69120, Heidelberg, Germany.; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany., Wu Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Liu HK; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. l.haikun@dkfz.de.; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China. l.haikun@dkfz.de.
Source: NPJ precision oncology [NPJ Precis Oncol] 2024 Jan 26; Vol. 8 (1), pp. 19. Date of Electronic Publication: 2024 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs.
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  Data: <searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. c.wang@dkfz.de.; Faculty of Medicine, Heidelberg University, Im Neuenheimer Feld 672, 69120, Heidelberg, Germany. c.wang@dkfz.de.; Department of Thyroid Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China. c.wang@dkfz.de.<br /><searchLink fieldCode="AU" term="%22Sun+M%22">Sun M</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shao+C%22">Shao C</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlicker+L%22">Schlicker L</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zhuo+Y%22">Zhuo Y</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Harim+Y%22">Harim Y</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Peng+T%22">Peng T</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tian+W%22">Tian W</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stöffler+N%22">Stöffler N</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Helm+D%22">Helm D</searchLink>; Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chu+Y%22">Chu Y</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fu+B%22">Fu B</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jin+X%22">Jin X</searchLink>; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 200025, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mallm+JP%22">Mallm JP</searchLink>; Single-cell Open Lab, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mall+M%22">Mall M</searchLink>; Cell Fate Engineering and Disease Modeling Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; HITBR Hector Institute for Translational Brain Research gGmbH, 69120, Heidelberg, Germany.; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Schulze+A%22">Schulze A</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+HK%22">Liu HK</searchLink>; Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ); The DKFZ-ZMBH alliance, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. l.haikun@dkfz.de.; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China. l.haikun@dkfz.de.
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        Value: 10.1038/s41698-024-00500-5
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