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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

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Title: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.
Authors: San Gil R; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Pascovici D; Insight Stats, Croydon Park, NSW, Australia.; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Venturato J; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Brown-Wright H; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Mehta P; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Madrid San Martin L; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wu J; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Luan W; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Chui YK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Bademosi AT; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Swaminathan S; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Naidoo S; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Berning BA; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wright AL; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Keating SS; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Curtis MA; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Faull RLM; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Lee JD; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Ngo ST; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia., Lee A; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Morsch M; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Chung RS; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Scotter E; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lisowski L; Vector and Genome Engineering Facility, Children's Medical Research Institute, Westmead, NSW, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Mirzaei M; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Walker AK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. adam.walker@uq.edu.au.
Source: Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1508. Date of Electronic Publication: 2024 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.
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  Data: <searchLink fieldCode="AU" term="%22San+Gil+R%22">San Gil R</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Pascovici+D%22">Pascovici D</searchLink>; Insight Stats, Croydon Park, NSW, Australia.; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Venturato+J%22">Venturato J</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Brown-Wright+H%22">Brown-Wright H</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Mehta+P%22">Mehta P</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Madrid+San+Martin+L%22">Madrid San Martin L</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Luan+W%22">Luan W</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Chui+YK%22">Chui YK</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Bademosi+AT%22">Bademosi AT</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Swaminathan+S%22">Swaminathan S</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Naidoo+S%22">Naidoo S</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Berning+BA%22">Berning BA</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Wright+AL%22">Wright AL</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Keating+SS%22">Keating SS</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Curtis+MA%22">Curtis MA</searchLink>; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Faull+RLM%22">Faull RLM</searchLink>; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lee+JD%22">Lee JD</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Ngo+ST%22">Ngo ST</searchLink>; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+A%22">Lee A</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Morsch+M%22">Morsch M</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+RS%22">Chung RS</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Scotter+E%22">Scotter E</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lisowski+L%22">Lisowski L</searchLink>; Vector and Genome Engineering Facility, Children's Medical Research Institute, Westmead, NSW, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mirzaei+M%22">Mirzaei M</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Walker+AK%22">Walker AK</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. adam.walker@uq.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1508. <i>Date of Electronic Publication: </i>2024 Feb 19.
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