Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes.
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| Title: | Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. |
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| Authors: | Sanchez A; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Ortega P; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Sakhtemani R; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Manjunath L; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Oh S; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Bournique E; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Becker A; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA., Kim K; Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA, USA., Durfee C; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, USA., Temiz NA; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Chen XS; Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA, USA., Harris RS; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX, USA., Lawrence MS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Buisson R; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA. rbuisson@uci.edu.; Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA. rbuisson@uci.edu.; Department of Pharmaceutical Sciences, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA. rbuisson@uci.edu. |
| Source: | Nature communications [Nat Commun] 2024 Mar 18; Vol. 15 (1), pp. 2370. Date of Electronic Publication: 2024 Mar 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-45909-5 |
