New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses.

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Title: New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses.
Authors: Siniavin AE; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia. Electronic address: andreysi93@ya.ru., Gushchin VA; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Department of Medical Genetics, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991, Moscow, Russia; Department of Virology, Faculty of Biology Lomonosov Moscow State University, 119234, Moscow, Russia. Electronic address: wowaniada@yandex.ru., Shastina NS; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571, Moscow, Russia., Darnotuk ES; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571, Moscow, Russia., Luyksaar SI; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Russu LI; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Inshakova AM; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571, Moscow, Russia., Shidlovskaya EV; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Vasina DV; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Kuznetsova NA; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Savina DM; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Zorkov ID; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Dolzhikova IV; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Sheremet AB; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Logunov DY; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Zigangirova NA; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia., Gintsburg AL; Department of Epidemiology, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, 123098, Moscow, Russia; Department of Infectology and Virology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119435, Moscow, Russia.
Source: Antiviral research [Antiviral Res] 2024 May; Vol. 225, pp. 105871. Date of Electronic Publication: 2024 Mar 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-9096
DOI:10.1016/j.antiviral.2024.105871