Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones.

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Title: Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones.
Authors: Denisenko E; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia. elena.denisenko@perkins.org.au., de Kock L; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada., Tan A; Anatomical Pathology Department, Clinipath, Sonic Healthcare, Perth, WA, 6017, Australia., Beasley AB; Centre for Precision Health, Edith Cowan University, Joondalup, WA, 6027, Australia., Beilin M; Department of Gynaecological Oncology, Bendat Family Comprehensive Cancer Centre, St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA, 6008, Australia., Jones ME; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Hou R; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Muirí DÓ; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Bilic S; Department of Gynaecological Oncology, Bendat Family Comprehensive Cancer Centre, St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA, 6008, Australia., Mohan GRKA; Department of Gynaecological Oncology, Bendat Family Comprehensive Cancer Centre, St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA, 6008, Australia.; School of Medicine, University of Notre Dame, Fremantle, WA, 6160, Australia., Salfinger S; Western Australian Gynae and Surgery, Perth, WA, Australia., Fox S; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Hmon KPW; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Yeow Y; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia., Kim Y; NanoString Technologies, Seattle, WA, USA., John R; NanoString Technologies, Seattle, WA, USA., Gilderman TS; NanoString Technologies, Seattle, WA, USA., Killingbeck E; NanoString Technologies, Seattle, WA, USA., Gray ES; Centre for Precision Health, Edith Cowan University, Joondalup, WA, 6027, Australia., Cohen PA; Division of Obstetrics and Gynaecology, Medical School, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia. paul.cohen@uwa.edu.au.; Institute for Health Research, The University of Notre Dame Australia, 32 Mouat Street Fremantle, Fremantle, WA, 6160, Australia. paul.cohen@uwa.edu.au., Yu Y; Division of Obstetrics and Gynaecology, Medical School, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia. yu.yu@curtin.edu.au.; Curtin Medical School, Curtin University, 410 Koorliny Way, Bentley, WA, 6102, Australia. yu.yu@curtin.edu.au.; Curtin Health Innovation Research Institute, Curtin University B305, Bentley, WA, 6102, Australia. yu.yu@curtin.edu.au., Forrest ARR; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia. alistair.forrest@gmail.com.
Source: Nature communications [Nat Commun] 2024 Apr 03; Vol. 15 (1), pp. 2860. Date of Electronic Publication: 2024 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-024-47271-y