Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment.
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| Title: | Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment. |
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| Authors: | Keller MD; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; Division of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.; GW Cancer Center, George Washington University School of Medicine, Washington, DC, USA., Hanley PJ; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; GW Cancer Center, George Washington University School of Medicine, Washington, DC, USA.; Division of Blood and Marrow Transplantation, Children's National Hospital, Washington, DC, USA., Chi YY; Department of Pediatrics and Preventative Medicine, University of Southern California, Los Angeles, CA, USA., Aguayo-Hiraldo P; Cancer and blood disease institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA., Dvorak CC; Division of Pediatric Allergy, Immunology, and BMT, University of California San Francisco, San Francisco, CA, USA., Verneris MR; Department of Pediatrics and Division of Child's Cancer and Blood Disorders, Children's Hospital Colorado and University of Colorado, Denver, CO, USA., Kohn DB; Department of Microbiology, Immunology & Molecular Genetics and Department of Pediatrics David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Division of Hematology/Oncology, University of California, Los Angeles, Los Angeles, CA, USA., Pai SY; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Dávila Saldaña BJ; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; Division of Blood and Marrow Transplantation, Children's National Hospital, Washington, DC, USA., Hanisch B; Division of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA., Quigg TC; Pediatric Blood & Bone Marrow Transplant and Cellular Therapy, Helen DeVos Children's Hospital, Grand Rapids, MI, USA., Adams RH; Center for Cancer and Blood Disorders, Phoenix Children's/Mayo Clinic Arizona, Phoenix, AZ, USA., Dahlberg A; Clinical Research Division, Fred Hutch Cancer Center/Seattle Children's Hospital/University of Washington, Seattle, WA, USA., Chandrakasan S; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Hasan H; Cancer and blood disease institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA., Malvar J; Cancer and blood disease institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA., Jensen-Wachspress MA; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Lazarski CA; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Sani G; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Idso JM; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Lang H; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Chansky P; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., McCann CD; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Tanna J; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Abraham AA; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; GW Cancer Center, George Washington University School of Medicine, Washington, DC, USA.; Division of Blood and Marrow Transplantation, Children's National Hospital, Washington, DC, USA., Webb JL; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; Division of Hematology, Children's National Hospital, Washington, DC, USA., Shibli A; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA., Keating AK; Pediatric Stem Cell Transplant, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA., Satwani P; Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Columbia University Medical Center, New York, NY, USA., Muranski P; Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Columbia University Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA., Hall E; Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Children's Mercy Kansas City, Kansas City, MO, USA., Eckrich MJ; Pediatric Transplant and Cellular Therapy, Levine Children's Hospital, Wake Forest School of Medicine, Charlotte, NC, USA., Shereck E; Division of Hematology and Oncology, Oregon Health & Science Univ, Portland, OR, USA., Miller H; Center for Cancer and Blood Disorders, Phoenix Children's/Mayo Clinic Arizona, Phoenix, AZ, USA., Mamcarz E; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Agarwal R; Division of Pediatric Hematology/Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University, Palo Alto, CA, USA., De Oliveira SN; Division of Hematology/Oncology, University of California, Los Angeles, Los Angeles, CA, USA., Vander Lugt MT; Division of Pediatric Hematology/Oncology/BMT, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA., Ebens CL; Division of Pediatric Blood and Marrow Transplant & Cellular Therapy, University of Minnesota MHealth Fairview Masonic Children's Hospital, Minneapolis, MI, USA., Aquino VM; Division of Pediatric Hematology/Oncology, University of Texas, Southwestern Medical Center Dallas, Dallas, TX, USA., Bednarski JJ; Department of Pediatrics, Division of Pediatric Hematology and Oncology, Washington University School of Medicine, St Louis, MO, USA., Chu J; Division of Pediatric Allergy, Immunology, and BMT, University of California San Francisco, San Francisco, CA, USA., Parikh S; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Whangbo J; Cancer and Blood Disorders Center, Dana Farber Institute and Boston Children's Hospital, Boston, MA, USA., Lionakis M; Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Zambidis ET; Pediatric Blood and Marrow Transplantation Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gourdine E; Cancer and blood disease institute, Children's Hospital of Los Angeles, Los Angeles, CA, USA., Bollard CM; Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.; GW Cancer Center, George Washington University School of Medicine, Washington, DC, USA.; Division of Blood and Marrow Transplantation, Children's National Hospital, Washington, DC, USA., Pulsipher MA; Division of Pediatric Hematology/Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA. michael.pulsipher@hci.utah.edu. |
| Source: | Nature communications [Nat Commun] 2024 Apr 18; Vol. 15 (1), pp. 3258. Date of Electronic Publication: 2024 Apr 18. |
| Publication Type: | Multicenter Study; Clinical Trial, Phase II; Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-47057-2 |
