Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
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| Title: | Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. |
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| Authors: | Vandermeulen L; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Geric I; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Fumagalli L; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Kreir M; Preclinical Development & Safety, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Lu A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Nonneman A; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Premereur J; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Wolfs L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Policarpo R; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Fattorelli N; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., De Bondt A; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Van Den Wyngaert I; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Asselbergh B; Neuromics Support Facility, VIB Center for Molecular Neurology, University of Antwerp, 2610, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Fiers M; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK., De Strooper B; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK., d'Ydewalle C; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium. cvanoutr@its.jnj.com., Mancuso R; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be. |
| Source: | Molecular neurodegeneration [Mol Neurodegener] 2024 Apr 24; Vol. 19 (1), pp. 37. Date of Electronic Publication: 2024 Apr 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1750-1326 |
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| DOI: | 10.1186/s13024-024-00725-9 |
