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Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

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Title: Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
Authors: Vandermeulen L; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Geric I; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Fumagalli L; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Kreir M; Preclinical Development & Safety, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Lu A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Nonneman A; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Premereur J; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Wolfs L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Policarpo R; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., Fattorelli N; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium., De Bondt A; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Van Den Wyngaert I; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium., Asselbergh B; Neuromics Support Facility, VIB Center for Molecular Neurology, University of Antwerp, 2610, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Fiers M; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK., De Strooper B; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK., d'Ydewalle C; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium. cvanoutr@its.jnj.com., Mancuso R; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be.
Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Apr 24; Vol. 19 (1), pp. 37. Date of Electronic Publication: 2024 Apr 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Vandermeulen+L%22">Vandermeulen L</searchLink>; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Geric+I%22">Geric I</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Fumagalli+L%22">Fumagalli L</searchLink>; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Kreir+M%22">Kreir M</searchLink>; Preclinical Development & Safety, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Lu+A%22">Lu A</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Nonneman+A%22">Nonneman A</searchLink>; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Premereur+J%22">Premereur J</searchLink>; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Wolfs+L%22">Wolfs L</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Policarpo+R%22">Policarpo R</searchLink>; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Fattorelli+N%22">Fattorelli N</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Bondt+A%22">De Bondt A</searchLink>; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Den+Wyngaert+I%22">Van Den Wyngaert I</searchLink>; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Asselbergh+B%22">Asselbergh B</searchLink>; Neuromics Support Facility, VIB Center for Molecular Neurology, University of Antwerp, 2610, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Fiers+M%22">Fiers M</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK.<br /><searchLink fieldCode="AU" term="%22De+Strooper+B%22">De Strooper B</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium.; UK Dementia Research Institute, University College London, London, W1T 7NF, UK.<br /><searchLink fieldCode="AU" term="%22d'Ydewalle+C%22">d'Ydewalle C</searchLink>; Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, 2340, Beerse, Belgium. cvanoutr@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Mancuso+R%22">Mancuso R</searchLink>; VIB-KU Leuven Center for Brain & Disease Research, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, 3000, Belgium. Renzo.mancuso@uantwerpen.vib.be.; MIND Lab, VIB Center for Molecular Neurology, VIB, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be.; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium. Renzo.mancuso@uantwerpen.vib.be.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2024 Apr 24; Vol. 19 (1), pp. 37. <i>Date of Electronic Publication: </i>2024 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101266600 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217501326%22">17501326 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurodegener <i>Subsets: </i>MEDLINE
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