Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
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| Title: | Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. |
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| Authors: | Chen Z; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, 37232, TN, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Law PJ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Fernandez-Rozadilla C; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain., Ping J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Jia G; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Li C; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Shen Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Xie Y; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Timofeeva MN; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark., Thomas M; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Schmit SL; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, USA., Díez-Obrero V; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Devall M; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Moratalla-Navarro F; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Fernandez-Tajes J; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Palles C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Sherwood K; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Briggs SEW; Department of Public Health, Richard Doll Building, University of Oxford, Oxford, UK., Svinti V; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Donnelly K; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Farrington SM; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Blackmur J; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vaughan-Shaw PG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lu Y; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Broderick P; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Studd J; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Conti DV; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Schumacher FR; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Melas M; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Rennert G; Clalit National Cancer Control Center, Haifa, Israel.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Obón-Santacana M; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Martín-Sánchez V; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Biomedicine Institute, University of León, León, Spain., Oh JH; Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea., Kim J; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea., Jee SH; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Jung KJ; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea., Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea., Shin A; Cancer Research Institute, Seoul National University, Seoul, South Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea., Ahn YO; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea., Kim DH; Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea., Oze I; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Matsuo K; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Tanikawa C; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Ren Z; School of Public Health, Sun Yat-sen University, Guangzhou, China., Gao YT; State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Jia WH; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Win AK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Pai RK; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA., Figueiredo JC; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Haile RW; Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, Los Angeles, CA, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada., Woods MO; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John, ON, Canada., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; School of Public Health, University of Washington, Seattle, WA, USA., Duggan D; City of Hope National Medical Center, Translational Genomics Research Institute, Phoenix, AZ, USA., Cheadle JP; Institute of Medical Genetics, Cardiff University, Cardiff, UK., Kaplan R; MRC Clinical Trials Unit, Medical Research Council, Cardiff, UK., Kerr R; Department of Oncology, University of Oxford, Oxford, UK., Kerr D; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Kirac I; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia., Böhm J; Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland., Mecklin JP; Central Finland Health Care District, Jyväskylä, Finland., Jousilahti P; Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Knekt P; Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Aaltonen LA; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Rissanen H; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Pukkala E; Faculty of Social Sciences, Tampere University, Tampere, Finland.; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland., Eriksson JG; Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland.; Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore.; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Cajuso T; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Hänninen U; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Kondelin J; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Palin K; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Tanskanen T; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Renkonen-Sinisalo L; Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland., Männistö S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Weinstein SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ruiz-Narvaez E; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer JR; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Slone Epidemiology Center at Boston University, Boston, MA, USA., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia., Platz EA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Visvanathan K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Ulrich CM; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Siegel E; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Brezina S; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria., Gsur A; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria., Campbell PT; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany.; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany., Slattery ML; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Potter JD; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand., Tsilidis KK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France., Murphy N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France., Castells A; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Castellví-Bel S; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Moreira L; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Shcherbina A; Department of Genetics, Stanford University, Stanford, CA, USA., Bishop DT; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Southey MC; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia., Idos GE; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., McDonnell KJ; Clalit National Cancer Control Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Abu-Ful Z; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Greenson JK; Clalit National Cancer Control Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Shulman K; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Lejbkowicz F; Clalit National Cancer Control Center, Haifa, Israel.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.; Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel., Offit K; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Su YR; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Steinfelder R; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Keku TO; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA., van Guelpen B; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Hudson TJ; 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Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Yen Y; Taipei Medical University, Taipei, Taiwan., Lenz HJ; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., White E; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA., Li L; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Doheny KF; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pugh E; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Shelford T; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chan AT; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Cruz-Correa M; Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico., Lindblom A; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Hunter DJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Joshi AD; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Schafmayer C; Department of General Surgery, University Hospital Rostock, Rostock, Germany., Scacheri PC; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Kundaje A; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Schoen RE; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Hampe J; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Stadler ZK; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Vodickova L; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Vymetalkova V; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Edlund CK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gauderman WJ; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shibata D; Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA., Toland A; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA., Markowitz S; Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA., Kim A; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., van Duijnhoven F; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Feskens EJM; Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands., Sakoda LC; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Gago-Dominguez M; Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Wolk A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Pardini B; Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy.; Italian Institute for Genomic Medicine, Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy., FitzGerald LM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Lee SC; National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ogino S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bien SA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Li CI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Prentice R; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bézieau S; Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France., Yamaji T; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Sawada N; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Iwasaki M; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Le Marchand L; Cancer Center, University of Hawaii, Honolulu, HI, USA., Wu AH; Preventative Medicine, University of Southern California, Los Angeles, CA, USA., Qu C; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., McNeil CE; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Coetzee G; Van Andel Research Institute, Grand Rapids, MI, USA., Hayward C; MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Harris SE; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Theodoratou E; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Reid S; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Walker M; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ooi LY; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore., Lau KS; Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Zhao H; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Dunlop MG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gruber SB; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Houlston RS; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Moreno V; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Casey G; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Tomlinson I; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu. |
| Source: | Nature communications [Nat Commun] 2024 Apr 26; Vol. 15 (1), pp. 3557. Date of Electronic Publication: 2024 Apr 26. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-47399-x |
