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Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network.

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Title: Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network.
Authors: Lewis ACF; Edmond and Lily Safra Center for Ethics, Harvard University, Cambridge, MA, USA; Department of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: aclewis@bwh.harvard.edu., Chisholm RL; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA., Connolly JJ; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Esplin ED; Invitae, San Francisco, CA, USA., Glessner J; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gordon A; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Pharmacology, Northwestern University, Evanston, IL, USA., Green RC; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ariadne Labs, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Harr M; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Holm IA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Jarvik GP; Division of Medical Genetics, Department of Medicine and Department of Genome Science, University of Washington Medical Center, Seattle, WA, USA., Karlson E; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Mass General Brigham Personalized Medicine, Boston, MA, USA., Kenny EE; Institute for Genomic Health, Icahn School of Medicine, New York City, NY, USA; Center for Clinical Translational Genomics, Icahn School of Medicine, New York City, NY, USA; Division of Genomic Medicine, Department of Medicine, Icahn School of Medicine, New York City, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, New York City, NY, USA., Kottyan L; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Lennon N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Linder JE; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Luo Y; Department of Preventive Medicine, Northwestern University, Evanston, IL, USA., Martin LJ; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Perez E; Mass General Brigham Personalized Medicine, Boston, MA, USA., Puckelwartz MJ; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Pharmacology, Northwestern University, Evanston, IL, USA., Rasmussen-Torvik LJ; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Preventive Medicine, Northwestern University, Evanston, IL, USA., Sabatello M; Center for Precision Medicine and Genomics, Department of Medicine, Columbia University Irving Medical Center, New York City, NY, USA; Division of Ethics, Department of Medical Humanities and Ethics, Columbia University Irving Medical Center, New York City, NY, USA., Sharp RR; Biomedical Ethics Program, Mayo Clinic, Rochester, MN, USA., Smoller JW; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA., Sterling R; Division of Genomics and Society, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Terek S; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Fullerton SM; Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.
Source: American journal of human genetics [Am J Hum Genet] 2024 Jun 06; Vol. 111 (6), pp. 999-1005. Date of Electronic Publication: 2024 Apr 29.
Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network.
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  Data: <searchLink fieldCode="AU" term="%22Lewis+ACF%22">Lewis ACF</searchLink>; Edmond and Lily Safra Center for Ethics, Harvard University, Cambridge, MA, USA; Department of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: aclewis@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Chisholm+RL%22">Chisholm RL</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Connolly+JJ%22">Connolly JJ</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Esplin+ED%22">Esplin ED</searchLink>; Invitae, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Glessner+J%22">Glessner J</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gordon+A%22">Gordon A</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Pharmacology, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Green+RC%22">Green RC</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ariadne Labs, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hakonarson+H%22">Hakonarson H</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Harr+M%22">Harr M</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Holm+IA%22">Holm IA</searchLink>; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jarvik+GP%22">Jarvik GP</searchLink>; Division of Medical Genetics, Department of Medicine and Department of Genome Science, University of Washington Medical Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Karlson+E%22">Karlson E</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Mass General Brigham Personalized Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kenny+EE%22">Kenny EE</searchLink>; Institute for Genomic Health, Icahn School of Medicine, New York City, NY, USA; Center for Clinical Translational Genomics, Icahn School of Medicine, New York City, NY, USA; Division of Genomic Medicine, Department of Medicine, Icahn School of Medicine, New York City, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kottyan+L%22">Kottyan L</searchLink>; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lennon+N%22">Lennon N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Linder+JE%22">Linder JE</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Department of Preventive Medicine, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Martin+LJ%22">Martin LJ</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Perez+E%22">Perez E</searchLink>; Mass General Brigham Personalized Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Puckelwartz+MJ%22">Puckelwartz MJ</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Pharmacology, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rasmussen-Torvik+LJ%22">Rasmussen-Torvik LJ</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Preventive Medicine, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sabatello+M%22">Sabatello M</searchLink>; Center for Precision Medicine and Genomics, Department of Medicine, Columbia University Irving Medical Center, New York City, NY, USA; Division of Ethics, Department of Medical Humanities and Ethics, Columbia University Irving Medical Center, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+RR%22">Sharp RR</searchLink>; Biomedical Ethics Program, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sterling+R%22">Sterling R</searchLink>; Division of Genomics and Society, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Terek+S%22">Terek S</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+WQ%22">Wei WQ</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fullerton+SM%22">Fullerton SM</searchLink>; Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.
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  Data: <searchLink fieldCode="JN" term="%220370475%22">American journal of human genetics</searchLink> [Am J Hum Genet] 2024 Jun 06; Vol. 111 (6), pp. 999-1005. <i>Date of Electronic Publication: </i>2024 Apr 29.
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