A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress.

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Title: A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress.
Authors: Hoang PM; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Torre D; Center for OncoGenomics and Innovative Therapeutics (COGIT), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jaynes P; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ho J; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Mohammed K; Center for OncoGenomics and Innovative Therapeutics (COGIT), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Alvstad E; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA.; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Lam WY; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Khanchandani V; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Lee JM; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Toh CMC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Lee RX; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Anbuselvan A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Lee S; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, South Korea., Sebra RP; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Martin J Walsh; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Marazzi I; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA.; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Kappei D; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Guccione E; Center for OncoGenomics and Innovative Therapeutics (COGIT), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetic and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Haematology-Oncology, National University Hospital, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Source: Science advances [Sci Adv] 2024 Jun 07; Vol. 10 (23), pp. eadm9589. Date of Electronic Publication: 2024 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adm9589