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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.

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Title: PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Authors: Shepard RM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Ghebremedhin A; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Pratumchai I; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Robinson SR; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Betts C; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Hu J; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sasik R; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA., Fisch KM; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Zak J; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Chen H; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Paradise M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Rivera J; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Amjad M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Uchiyama S; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Seo H; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Campos AD; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Dayao DA; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Piedra-Mora C; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Das S; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Hasteh F; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Russo H; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sun X; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Xu L; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Crotty Alexander LE; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Duran JM; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Odish M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Pretorius V; Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA., Kirchberger NC; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Chin SM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Von Schalscha T; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Cheresh D; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Morrey JD; Institute for Antiviral Research, Animal, Dairy, and Veterinary Science, Utah State University, Logan, UT 84322, USA., Alargova R; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., O'Connell B; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Martinot TA; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Patel SP; Department of Medicine/Medical Oncology, University of California, San Diego, La Jolla, CA 92093, USA., Nizet V; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Martinot AJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Coussens LM; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA., Teijaro JR; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Jul 03; Vol. 16 (754), pp. eadi6887. Date of Electronic Publication: 2024 Jul 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adi6887