First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors.

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Title: First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors.
Authors: Wermke M; Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany Martin.Wermke@uniklinikum-dresden.de.; National Center for Tumor Diseases, Dresden, Germany., Holderried TAW; Department of Hematology, Oncology, Immunooncology, Stem Cell Transplantation, and Rheumatology, University Hospital Bonn, Bonn, Germany., Luke JJ; Cancer Immunotherapeutics Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Morris VK; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center Division of Cancer Medicine, Houston, Texas, USA., Alsdorf WH; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section Pneumology, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Wetzko K; Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany., Andersson BS; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Parra ER; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Hossain MB; Immatics US, Inc, Houston, Texas, USA., Grund-Gröschke S; Immatics Biotechnologies GmbH, Tuebingen, Germany., Aslan K; Immatics Biotechnologies GmbH, Tuebingen, Germany., Satelli A; Immatics US, Inc, Houston, Texas, USA., Marisetty A; Immatics US, Inc, Houston, Texas, USA., Satam S; Immatics Biotechnologies GmbH, Tuebingen, Germany., Kalra M; Immatics US, Inc, Houston, Texas, USA., Hukelmann J; Immatics Biotechnologies GmbH, Tuebingen, Germany., Kursunel MA; Immatics Biotechnologies GmbH, Tuebingen, Germany., Pozo K; Immatics US, Inc, Houston, Texas, USA., Acs A; Immatics Biotechnologies GmbH, Tuebingen, Germany., Backert L; Immatics Biotechnologies GmbH, Tuebingen, Germany., Baumeister M; Immatics Biotechnologies GmbH, Tuebingen, Germany., Bunk S; Immatics Biotechnologies GmbH, Tuebingen, Germany., Wagner C; Immatics Biotechnologies GmbH, Tuebingen, Germany., Schoor O; Immatics Biotechnologies GmbH, Tuebingen, Germany., Mohamed AS; Immatics US, Inc, Houston, Texas, USA., Mayer-Mokler A; Immatics Biotechnologies GmbH, Tuebingen, Germany., Hilf N; Immatics Biotechnologies GmbH, Tuebingen, Germany., Krishna D; Immatics US, Inc, Houston, Texas, USA., Walter S; Immatics US, Inc, Houston, Texas, USA., Tsimberidou AM; Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Britten CM; Immatics Biotechnologies GmbH, Tuebingen, Germany.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jul 22; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 22.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2023-008668