In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.
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| Title: | In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor. |
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| Authors: | Sukhun R; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cremin P; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Xu D; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Zamora J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cheung J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Ashcraft L; Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, California, USA., Grillo MP; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, California, USA. |
| Source: | Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 686-700. Date of Electronic Publication: 2024 Aug 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1366-5928 |
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| DOI: | 10.1080/00498254.2024.2389407 |
