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In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.

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Title: In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.
Authors: Sukhun R; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cremin P; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Xu D; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Zamora J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cheung J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Ashcraft L; Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, California, USA., Grillo MP; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, California, USA.
Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 686-700. Date of Electronic Publication: 2024 Aug 09.
Publication Type: Journal Article
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Sukhun+R%22">Sukhun R</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cremin+P%22">Cremin P</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Zamora+J%22">Zamora J</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cheung+J%22">Cheung J</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Ashcraft+L%22">Ashcraft L</searchLink>; Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Grillo+MP%22">Grillo MP</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+BP%22">Morgan BP</searchLink>; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, California, USA.
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  Data: <searchLink fieldCode="JN" term="%221306665%22">Xenobiotica; the fate of foreign compounds in biological systems</searchLink> [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 686-700. <i>Date of Electronic Publication: </i>2024 Aug 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Informa+Healthcare%22">Informa Healthcare </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>1306665 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1366-5928 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200498254%22">00498254 </searchLink><i>NLM ISO Abbreviation: </i>Xenobiotica <i>Subsets: </i>MEDLINE
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        Value: 10.1080/00498254.2024.2389407
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              M: 09
              Text: 2024 Sep
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