Impact of Prior Chemotherapy on Response to Second-line Pembrolizumab in Urothelial Cancer: Exploratory Analysis of the Phase 3 KEYNOTE-045 Trial.

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Title: Impact of Prior Chemotherapy on Response to Second-line Pembrolizumab in Urothelial Cancer: Exploratory Analysis of the Phase 3 KEYNOTE-045 Trial.
Authors: de Wit R; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. Electronic address: r.dewit@erasmusmc.nl., Vaughn DJ; Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Fradet Y; Department of Surgery/Urology, CHU de Québec-Université Laval Research Center, Quebec, QC, Canada., Fong L; Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Climent MA; Department of Medical Oncology, Valencian Institute of Oncology (IVO Foundation), Valencia, Spain., Necchi A; Department of Medical Oncology, Vita-Salute San Raffaele University and IRCCS Ospedale San Raffaele, Milan, Italy., Petrylak DP; Department of Internal Medicine/Medical Oncology, Smilow Cancer Hospital, Yale New Haven Health, New Haven, CT, USA., Gerritsen WR; Department of Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Gurney H; Department of Medical Oncology, Westmead Hospital and Macquarie University, Sydney, NSW, Australia., Quinn DI; Developmental Therapeutics Program, USC Norris Comprehensive Cancer Center and Division of Cancer Medicine and Blood Diseases, Keck Medicine of USC, Los Angeles, CA, USA., Culine S; Department of Medical Oncology, Saint-Louis Hospital, Paris, France., Sternberg CN; Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York-Presbyterian, New York, NY, USA., Bajorin DF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Choueiri TK; Department of Medical Oncology, Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Xu J; Department of Medical Oncology, Merck & Co. Inc, Rahway, NJ, USA., Imai K; Department of Medical Oncology, Merck & Co. Inc, Rahway, NJ, USA., Homet Moreno B; Department of Medical Oncology, Merck & Co. Inc, Rahway, NJ, USA., Bellmunt J; Department of Medical Oncology, Dana-Farber Cancer Institute and IMIM Research Institute, Harvard Medical School, Boston, MA, USA., Lee JL; Division of Oncology, Department of Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, South Korea.
Source: European urology [Eur Urol] 2025 Nov; Vol. 88 (5), pp. 462-471. Date of Electronic Publication: 2024 Aug 22.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-7560
DOI:10.1016/j.eururo.2024.07.015