Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome.

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Title: Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome.
Authors: Mensah JA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA., Johnson K; Contract Site of the National Institute of Neurological Disorders and Stroke Epilepsy Therapy Screening Program, Salt Lake City, Utah, USA., Freeman T; Center for Human Toxicology, Salt Lake City, Utah, USA., Reilly CA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.; Center for Human Toxicology, Salt Lake City, Utah, USA., Rower JE; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.; Center for Human Toxicology, Salt Lake City, Utah, USA., Metcalf CS; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.; Contract Site of the National Institute of Neurological Disorders and Stroke Epilepsy Therapy Screening Program, Salt Lake City, Utah, USA., Wilcox KS; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.; Contract Site of the National Institute of Neurological Disorders and Stroke Epilepsy Therapy Screening Program, Salt Lake City, Utah, USA.
Source: Epilepsia [Epilepsia] 2024 Oct; Vol. 65 (10), pp. 3100-3114. Date of Electronic Publication: 2024 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1528-1167
DOI:10.1111/epi.18104