Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.
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| Title: | Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. |
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| Authors: | Caniels TG; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Medina-Ramìrez M; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Zhang S; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Kratochvil S; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Xian Y; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Koo JH; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Derking R; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Samsel J; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA.; Institute for Biomedical Sciences, George Washington University, Washington, DC, USA., van Schooten J; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Pecetta S; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Lamperti E; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Yuan M; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Carrasco MR; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Del Moral Sánchez I; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Allen JD; School of Biological Sciences, University of Southampton, Southampton, UK., Bouhuijs JH; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Yasmeen A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Ketas TJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Snitselaar JL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Bijl TPL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Martin IC; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Cupo A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Shirreff L; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Mason RD; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Roederer M; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Greene KM; Duke University Medical Center, Durham, NC, USA., Gao H; Duke University Medical Center, Durham, NC, USA., Silva CM; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Baken IJL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Tian M; Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Alt FW; Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton, UK., van Gils MJ; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Montefiori DC; Duke University Medical Center, Durham, NC, USA., McDermott AB; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Villinger FJ; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Koup RA; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Batista FD; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA.; Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Sanders RW; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. |
| Source: | Science immunology [Sci Immunol] 2024 Aug 30; Vol. 9 (98), pp. eadk9550. Date of Electronic Publication: 2024 Aug 30. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adk9550 |