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To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes.

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Title: To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes.
Authors: Le Huray KIP; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, U.K., Wörner TP; Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath Str. 11, 28199 Bremen, Germany., Moreira T; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, U.K., Dembek M; Purification Process Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Reinhardt-Szyba M; Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath Str. 11, 28199 Bremen, Germany., Devine PWA; Analytical Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Bond NJ; Analytical Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Fort KL; Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath Str. 11, 28199 Bremen, Germany.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Makarov AA; Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath Str. 11, 28199 Bremen, Germany.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Sobott F; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, U.K.
Source: ACS central science [ACS Cent Sci] 2024 Jul 26; Vol. 10 (8), pp. 1548-1561. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: eCollection Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2374-7943
DOI:10.1021/acscentsci.4c00462