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Pharmacokinetics of Efmoroctocog alfa by Two-Compartment Model Highlights Hemophilia A Patients with Biphasic Decay, Long Mean Residence Time, and Beta Half-Life.

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Title: Pharmacokinetics of Efmoroctocog alfa by Two-Compartment Model Highlights Hemophilia A Patients with Biphasic Decay, Long Mean Residence Time, and Beta Half-Life.
Authors: Morfini M; Italian Association of Hemophilia Centers (AICE), I 20120 Milan, Italy., Peyvandi F; Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCSS Ca' Granda Maggiore Hospital, 'Angelo Bianchi Bonomi', I 20120 Milan, Italy., Mancuso ME; Center for Thrombosis and Hemorrhagic Diseases, IRCCS ' Humanitas Research Hospital', Rozzano, I 20142 Milan, Italy., Marchesini E; Hemophilia Centre, Internal and Cardiovascular Medicine, 'Santa Maria della Misericordia' University Hospital, I 06100 Perugia, Italy., Tagliaferri A; Regional Reference Centre for Inherited Bleeding Disorders, University Hospital of Parma, I 43100 Parma, Italy., Gualtierotti R; Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCSS Ca' Granda Maggiore Hospital, 'Angelo Bianchi Bonomi', I 20120 Milan, Italy., Castaman G; Department of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, I 50139 Florence, Italy., Pollio B; Regional Reference Centre for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, 'Regina Margherita' Children Hospital, I 10100 Turin, Italy., Santoro C; Department of Hematology, University Hospital Policlinico 'Umberto I', I 00100 Rome, Italy., Banov L; Regional Reference Centre for Hemorrhagic Diseases, IRCCS Istituto 'Giannina Gaslini', I 16100 Genoa, Italy., Napolitano M; Hematology Unit, Thrombosis and Hemostasis Reference Regional Centre, University of Palermo, I 90100 Palermo, Italy., Preti PS; Department of Internal Medicine and Therapeutics, University of Pavia, I 27100 Pavia, Italy., Santoro RC; Regional Reference Centre for Hemophilia and Coagulation Diseases, Azienda Ospedaliera Pugliese 'Ciaccio', I 88100 Catanzaro, Italy., Coppola A; Regional Reference Centre for Inherited Bleeding Disorders, University Hospital of Parma, I 43100 Parma, Italy., Linari S; Department of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, I 50139 Florence, Italy., Santagostino E; SOBI, SE-11276 Stockholm, Sweden., Bernardi F; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, I 44121 Ferrara, Italy.
Source: Journal of clinical medicine [J Clin Med] 2024 Aug 23; Vol. 13 (17). Date of Electronic Publication: 2024 Aug 23.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetics of Efmoroctocog alfa by Two-Compartment Model Highlights Hemophilia A Patients with Biphasic Decay, Long Mean Residence Time, and Beta Half-Life.
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  Data: <searchLink fieldCode="AU" term="%22Morfini+M%22">Morfini M</searchLink>; Italian Association of Hemophilia Centers (AICE), I 20120 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Peyvandi+F%22">Peyvandi F</searchLink>; Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCSS Ca' Granda Maggiore Hospital, 'Angelo Bianchi Bonomi', I 20120 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mancuso+ME%22">Mancuso ME</searchLink>; Center for Thrombosis and Hemorrhagic Diseases, IRCCS ' Humanitas Research Hospital', Rozzano, I 20142 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marchesini+E%22">Marchesini E</searchLink>; Hemophilia Centre, Internal and Cardiovascular Medicine, 'Santa Maria della Misericordia' University Hospital, I 06100 Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Tagliaferri+A%22">Tagliaferri A</searchLink>; Regional Reference Centre for Inherited Bleeding Disorders, University Hospital of Parma, I 43100 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Gualtierotti+R%22">Gualtierotti R</searchLink>; Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCSS Ca' Granda Maggiore Hospital, 'Angelo Bianchi Bonomi', I 20120 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Castaman+G%22">Castaman G</searchLink>; Department of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, I 50139 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Pollio+B%22">Pollio B</searchLink>; Regional Reference Centre for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, 'Regina Margherita' Children Hospital, I 10100 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Santoro+C%22">Santoro C</searchLink>; Department of Hematology, University Hospital Policlinico 'Umberto I', I 00100 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Banov+L%22">Banov L</searchLink>; Regional Reference Centre for Hemorrhagic Diseases, IRCCS Istituto 'Giannina Gaslini', I 16100 Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Napolitano+M%22">Napolitano M</searchLink>; Hematology Unit, Thrombosis and Hemostasis Reference Regional Centre, University of Palermo, I 90100 Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Preti+PS%22">Preti PS</searchLink>; Department of Internal Medicine and Therapeutics, University of Pavia, I 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Santoro+RC%22">Santoro RC</searchLink>; Regional Reference Centre for Hemophilia and Coagulation Diseases, Azienda Ospedaliera Pugliese 'Ciaccio', I 88100 Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Coppola+A%22">Coppola A</searchLink>; Regional Reference Centre for Inherited Bleeding Disorders, University Hospital of Parma, I 43100 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Linari+S%22">Linari S</searchLink>; Department of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, I 50139 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Santagostino+E%22">Santagostino E</searchLink>; SOBI, SE-11276 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bernardi+F%22">Bernardi F</searchLink>; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, I 44121 Ferrara, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101606588%22">Journal of clinical medicine</searchLink> [J Clin Med] 2024 Aug 23; Vol. 13 (17). <i>Date of Electronic Publication: </i>2024 Aug 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101606588 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2077-0383 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220770383%22">20770383 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Med <i>Subsets: </i>PubMed not MEDLINE
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