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AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers.

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Title: AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers.
Authors: Belmontes B; Amgen Research, Thousand Oaks, California., Slemmons KK; Amgen Research, Thousand Oaks, California., Su C; Amgen Research, South San Francisco, California., Liu S; Amgen Research, Thousand Oaks, California., Policheni AN; Amgen Research, Thousand Oaks, California., Moriguchi J; Amgen Research, Thousand Oaks, California., Tan H; Amgen Research, Thousand Oaks, California., Xie F; Amgen Research, South San Francisco, California., Aiello DA; Amgen Research, Thousand Oaks, California., Yang Y; Amgen Research, Thousand Oaks, California., Lazaro R; Amgen Research, Thousand Oaks, California., Aeffner F; Amgen Research, South San Francisco, California., Rees MG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Roth JA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Vestergaard M; Amgen Research, Copenhagen, Denmark., Cowland S; Amgen Research, Copenhagen, Denmark., Andersson J; Amgen Research, Copenhagen, Denmark., Sarvary I; Amgen Research, Copenhagen, Denmark., Chen Q; Amgen Research, Thousand Oaks, California., Sharma P; Amgen Research, Thousand Oaks, California., Lopez P; Amgen Research, Thousand Oaks, California., Tamayo N; Amgen Research, Thousand Oaks, California., Pettus LH; Amgen Research, Thousand Oaks, California., Ghimire-Rijal S; Amgen Research, Thousand Oaks, California., Mukund S; Amgen Research, South San Francisco, California., Allen JR; Amgen Research, Thousand Oaks, California., DeVoss J; Amgen Research, South San Francisco, California., Coxon A; Amgen Research, Thousand Oaks, California., Rodon J; MD Anderson, Houston, Texas., Ghiringhelli F; Centre Georges François Leclerc, Dijon, France., Penel N; Centre Oscar Lambret, Lille, France., Prenen H; Universitair Ziekenhuis Antwerpen, Edegem, Belgium., Glad S; Amgen Research, Copenhagen, Denmark., Chuang CH; Amgen Research, South San Francisco, California., Keyvanjah K; Amgen Research, Thousand Oaks, California., Townsley DM; Amgen Research, Thousand Oaks, California., Butler JR; Amgen Research, Thousand Oaks, California., Bourbeau MP; Amgen Research, Thousand Oaks, California., Caenepeel S; Amgen Research, Thousand Oaks, California., Hughes PE; Amgen Research, Thousand Oaks, California.
Source: Cancer discovery [Cancer Discov] 2025 Jan 13; Vol. 15 (1), pp. 139-161.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers.
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Amgen Research, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Allen+JR%22">Allen JR</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22DeVoss+J%22">DeVoss J</searchLink>; Amgen Research, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Coxon+A%22">Coxon A</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Rodon+J%22">Rodon J</searchLink>; MD Anderson, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Ghiringhelli+F%22">Ghiringhelli F</searchLink>; Centre Georges François Leclerc, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Penel+N%22">Penel N</searchLink>; Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Prenen+H%22">Prenen H</searchLink>; Universitair Ziekenhuis Antwerpen, Edegem, Belgium.<br /><searchLink fieldCode="AU" term="%22Glad+S%22">Glad S</searchLink>; Amgen Research, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Chuang+CH%22">Chuang CH</searchLink>; Amgen Research, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Keyvanjah+K%22">Keyvanjah K</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Townsley+DM%22">Townsley DM</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Butler+JR%22">Butler JR</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Bourbeau+MP%22">Bourbeau MP</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Caenepeel+S%22">Caenepeel S</searchLink>; Amgen Research, Thousand Oaks, California.<br /><searchLink fieldCode="AU" term="%22Hughes+PE%22">Hughes PE</searchLink>; Amgen Research, Thousand Oaks, California.
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  Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2025 Jan 13; Vol. 15 (1), pp. 139-161.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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              Text: 2025 Jan 13
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