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Colchicine treatment in amyotrophic lateral sclerosis: safety, biological and clinical effects in a randomized clinical trial.

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Title: Colchicine treatment in amyotrophic lateral sclerosis: safety, biological and clinical effects in a randomized clinical trial.
Authors: Gianferrari G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Cuoghi Costantini R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy., Crippa V; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., Carra S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Bonetto V; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy., Pansarasa O; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Cereda C; Department of Pediatrics, Center of Functional Genomics and Rare diseases, 'V. Buzzi' Children's Hospital, Milan 20154, Italy., Zucchi E; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Neurosciences PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy., Martinelli I; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy., Simonini C; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Vicini R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy., Fini N; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Trojsi F; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy., Passaniti C; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy., Ticozzi N; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan 20122, Italy., Doretti A; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy., Diamanti L; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Fiamingo G; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Conte A; Department of Aging, Neurological, Orthopedic and Head-Neck Sciences, Adult NEMO Clinical Center, Unit of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy., Dalla Bella E; 3rd Neurology Unit and Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy., D'Errico E; Department of Basic Medical Sciences, ALS Center, Neurosciences and Sense Organs, University of Bari, Bari 70124, Italy., Scarian E; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Pasetto L; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy., Antoniani F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Galli V; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Casarotto E; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., D'Amico R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy.; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena 41124, Italy., Poletti A; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., Mandrioli J; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.
Corporate Authors: Co-ALS Investigators Group
Source: Brain communications [Brain Commun] 2024 Sep 05; Vol. 6 (5), pp. fcae304. Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Colchicine treatment in amyotrophic lateral sclerosis: safety, biological and clinical effects in a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Gianferrari+G%22">Gianferrari G</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.<br /><searchLink fieldCode="AU" term="%22Cuoghi+Costantini+R%22">Cuoghi Costantini R</searchLink>; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Crippa+V%22">Crippa V</searchLink>; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Carra+S%22">Carra S</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Bonetto+V%22">Bonetto V</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Pansarasa+O%22">Pansarasa O</searchLink>; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Cereda+C%22">Cereda C</searchLink>; Department of Pediatrics, Center of Functional Genomics and Rare diseases, 'V. Buzzi' Children's Hospital, Milan 20154, Italy.<br /><searchLink fieldCode="AU" term="%22Zucchi+E%22">Zucchi E</searchLink>; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Neurosciences PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Martinelli+I%22">Martinelli I</searchLink>; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Simonini+C%22">Simonini C</searchLink>; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.<br /><searchLink fieldCode="AU" term="%22Vicini+R%22">Vicini R</searchLink>; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Fini+N%22">Fini N</searchLink>; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.<br /><searchLink fieldCode="AU" term="%22Trojsi+F%22">Trojsi F</searchLink>; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Passaniti+C%22">Passaniti C</searchLink>; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Ticozzi+N%22">Ticozzi N</searchLink>; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Doretti+A%22">Doretti A</searchLink>; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy.<br /><searchLink fieldCode="AU" term="%22Diamanti+L%22">Diamanti L</searchLink>; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Fiamingo+G%22">Fiamingo G</searchLink>; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Conte+A%22">Conte A</searchLink>; Department of Aging, Neurological, Orthopedic and Head-Neck Sciences, Adult NEMO Clinical Center, Unit of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.<br /><searchLink fieldCode="AU" term="%22Dalla+Bella+E%22">Dalla Bella E</searchLink>; 3rd Neurology Unit and Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy.<br /><searchLink fieldCode="AU" term="%22D'Errico+E%22">D'Errico E</searchLink>; Department of Basic Medical Sciences, ALS Center, Neurosciences and Sense Organs, University of Bari, Bari 70124, Italy.<br /><searchLink fieldCode="AU" term="%22Scarian+E%22">Scarian E</searchLink>; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Pasetto+L%22">Pasetto L</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Antoniani+F%22">Antoniani F</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Galli+V%22">Galli V</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.<br /><searchLink fieldCode="AU" term="%22Casarotto+E%22">Casarotto E</searchLink>; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22D'Amico+R%22">D'Amico R</searchLink>; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy.; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena 41124, Italy.<br /><searchLink fieldCode="AU" term="%22Poletti+A%22">Poletti A</searchLink>; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Mandrioli+J%22">Mandrioli J</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101755125 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-1297 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226321297%22">26321297 </searchLink><i>NLM ISO Abbreviation: </i>Brain Commun <i>Subsets: </i>PubMed not MEDLINE
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