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NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment.

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Title: NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment.
Authors: de la Calle-Fabregat C; Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain.; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Calafell-Segura J; Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain., Gardet M; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Dunsmore G; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Mulder K; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Ciudad L; Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain., Silvin A; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Moreno-Càceres J; Preclinical and Experimental Research in Thoracic Tumors (PReTT), Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Spain., Corbí ÁL; Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain., Muñoz-Pinedo C; Preclinical and Experimental Research in Thoracic Tumors (PReTT), Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Spain., Michels J; INSERM UMR1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Faculté de Médecine, Université Paris-Saclay, 94805 Villejuif, France.; Département de Médecine Oncologique, Gustave Roussy, 94805 Villejuif, France., Gouy S; Department of Surgical Oncology, Gustave Roussy, 94805 Villejuif, France., Dutertre CA; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Rodríguez-Ubreva J; Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain., Ginhoux F; INSERM UMR1015, Gustave Roussy Cancer Campus, 94805 Villejuif, France., Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain.; Epigenetics in Inflammatory and Metabolic Diseases Laboratory, Health Science Center (HSC), East China Normal University (ECNU), Shanghai 200241, China.
Source: Science advances [Sci Adv] 2024 Sep 20; Vol. 10 (38), pp. eadq5226. Date of Electronic Publication: 2024 Sep 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adq5226