Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.

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Bibliographic Details
Title: Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.
Authors: Blazanin N; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Liang X; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Mahmud I; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Kim E; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Martinez S; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Tan L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Chan W; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Anvar NE; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Ha MJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA., Qudratullah M; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Minelli R; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Peoples M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Lorenzi P; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Hart T; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Lissanu Y; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2024.09.16.613317