Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.
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| Title: | Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity. |
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| Authors: | Blazanin N; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Liang X; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Mahmud I; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Kim E; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Martinez S; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Tan L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Chan W; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Anvar NE; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Ha MJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA., Qudratullah M; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Minelli R; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Peoples M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Lorenzi P; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Hart T; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Lissanu Y; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39345502 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Blazanin+N%22">Blazanin N</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Mahmud+I%22">Mahmud I</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Kim+E%22">Kim E</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Martinez+S%22">Martinez S</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Chan+W%22">Chan W</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Anvar+NE%22">Anvar NE</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Ha+MJ%22">Ha MJ</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Qudratullah+M%22">Qudratullah M</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Minelli+R%22">Minelli R</searchLink>; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Peoples+M%22">Peoples M</searchLink>; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Lorenzi+P%22">Lorenzi P</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Hart+T%22">Hart T</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Lissanu+Y%22">Lissanu Y</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2024 Sep 20. <i>Date of Electronic Publication: </i>2024 Sep 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39345502 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2024.09.16.613317 Languages: – Code: eng Text: English Titles: – TitleFull: Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Blazanin N – PersonEntity: Name: NameFull: Liang X – PersonEntity: Name: NameFull: Mahmud I – PersonEntity: Name: NameFull: Kim E – PersonEntity: Name: NameFull: Martinez S – PersonEntity: Name: NameFull: Tan L – PersonEntity: Name: NameFull: Chan W – PersonEntity: Name: NameFull: Anvar NE – PersonEntity: Name: NameFull: Ha MJ – PersonEntity: Name: NameFull: Qudratullah M – PersonEntity: Name: NameFull: Minelli R – PersonEntity: Name: NameFull: Peoples M – PersonEntity: Name: NameFull: Lorenzi P – PersonEntity: Name: NameFull: Hart T – PersonEntity: Name: NameFull: Lissanu Y IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 09 Text: 2024 Sep 20 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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