Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.

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Title: Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.
Authors: Blazanin N; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Liang X; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Mahmud I; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Kim E; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Martinez S; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Tan L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Chan W; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Anvar NE; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Ha MJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA., Qudratullah M; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center., Minelli R; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Peoples M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA., Lorenzi P; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Hart T; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center., Lissanu Y; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Blazanin+N%22">Blazanin N</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Mahmud+I%22">Mahmud I</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Kim+E%22">Kim E</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Martinez+S%22">Martinez S</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Chan+W%22">Chan W</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Anvar+NE%22">Anvar NE</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Ha+MJ%22">Ha MJ</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Qudratullah+M%22">Qudratullah M</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Minelli+R%22">Minelli R</searchLink>; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Peoples+M%22">Peoples M</searchLink>; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Lorenzi+P%22">Lorenzi P</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Hart+T%22">Hart T</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Lissanu+Y%22">Lissanu Y</searchLink>; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2024 Sep 20. <i>Date of Electronic Publication: </i>2024 Sep 20.
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        Value: 10.1101/2024.09.16.613317
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