The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice.

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Title: The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice.
Authors: Wang Q; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand., Leask MP; University of Alabama, Birmingham, AL, USA., Lee K; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand., Jaiswal J; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand., Kallingappa P; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Dissanayake W; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand., Puli'uvea C; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Biomedicine and Diagnostics, Auckland University of Technology, Auckland, New Zealand., O'Sullivan C; Moko Foundation, Kaitaia, New Zealand., Watson H; Paratene Ngata Research Centre, Ngati Porou Oranga, Te Puia Springs, New Zealand., Wilcox P; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Statistics, University of Otago, Dunedin, New Zealand., Murphy R; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Medicine, University of Auckland, Auckland, New Zealand.; Auckland Diabetes Centre, Te Whatu Ora Health New Zealand, Te Toka Tumai, New Zealand., Merry TL; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Nutrition, University of Auckland, Auckland, New Zealand., Shepherd PR; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.; Maurice Wilkins Centre, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.
Source: Diabetologia [Diabetologia] 2025 Mar; Vol. 68 (3), pp. 537-548. Date of Electronic Publication: 2024 Oct 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Leask+MP%22">Leask MP</searchLink>; University of Alabama, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Jaiswal+J%22">Jaiswal J</searchLink>; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Kallingappa+P%22">Kallingappa P</searchLink>; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Dissanayake+W%22">Dissanayake W</searchLink>; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Puli'uvea+C%22">Puli'uvea C</searchLink>; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Biomedicine and Diagnostics, Auckland University of Technology, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+C%22">O'Sullivan C</searchLink>; Moko Foundation, Kaitaia, New Zealand.<br /><searchLink fieldCode="AU" term="%22Watson+H%22">Watson H</searchLink>; Paratene Ngata Research Centre, Ngati Porou Oranga, Te Puia Springs, New Zealand.<br /><searchLink fieldCode="AU" term="%22Wilcox+P%22">Wilcox P</searchLink>; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Statistics, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Murphy+R%22">Murphy R</searchLink>; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Medicine, University of Auckland, Auckland, New Zealand.; Auckland Diabetes Centre, Te Whatu Ora Health New Zealand, Te Toka Tumai, New Zealand.<br /><searchLink fieldCode="AU" term="%22Merry+TL%22">Merry TL</searchLink>; Maurice Wilkins Centre, Auckland, New Zealand.; Department of Nutrition, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Shepherd+PR%22">Shepherd PR</searchLink>; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.; Maurice Wilkins Centre, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand. peter.shepherd@auckland.ac.nz.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2025 Mar; Vol. 68 (3), pp. 537-548. <i>Date of Electronic Publication: </i>2024 Oct 18.
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