Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.

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Title: Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.
Authors: Ying K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.; T. H. Chan School of Public Health, Harvard University, Boston, USA., Castro JP; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.; i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Aging and Aneuploidy Laboratory, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Shindyapina AV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.; Retro Biosciences, Redwood City, USA., Tyshkovskiy A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA., Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA., Goeminne LJE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA., Milman S; Department of Genetics, Albert Einstein College of Medicine, Bronx, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, USA., Zhang ZD; Department of Genetics, Albert Einstein College of Medicine, Bronx, USA., Barzilai N; Department of Genetics, Albert Einstein College of Medicine, Bronx, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, USA., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. vgladyshev@rics.bwh.harvard.edu.
Source: Nature communications [Nat Commun] 2024 Oct 19; Vol. 15 (1), pp. 9030. Date of Electronic Publication: 2024 Oct 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-024-52967-2