Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.

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Title: Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Authors: Coate KC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Dai C; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Singh A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Stanley J; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Covington BA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Bradley A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Oladipupo F; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gong Y; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Wisniewski S; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sellick K; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Spears E; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Schornack AMR; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Bustabad A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rodgers T; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dey N; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Greiner DL; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yan H; REMD Biotherapeutics Inc., Camarillo, CA, USA., Powers AC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address: al.powers@vumc.org., Chen W; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address: wenbiao.chen@vanderbilt.edu., Dean ED; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address: danielle.dean@vumc.org.
Source: Molecular metabolism [Mol Metab] 2024 Dec; Vol. 90, pp. 102050. Date of Electronic Publication: 2024 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2212-8778
DOI:10.1016/j.molmet.2024.102050