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Negative effect of treatment with mGluR5 negative allosteric modulator AFQ056 on blood biomarkers in young individuals with Fragile X syndrome.

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Title: Negative effect of treatment with mGluR5 negative allosteric modulator AFQ056 on blood biomarkers in young individuals with Fragile X syndrome.
Authors: Protic D; Faculty of Medicine, Department of Pharmacology, Clinical Pharmacology, and Toxicology, University of Belgrade, Belgrade, Serbia.; Fragile X Clinic, Special Hospital for Cerebral Palsy and Developmental Neurology, Belgrade, Serbia., Breeze E; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.; MIND Institute, University of California Davis, Sacramento, CA, USA., Mendoza G; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA., Zafarullah M; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA., Abbeduto L; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA., Hagerman R; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Pediatrics, University of California Davis, Sacramento, CA, USA., Coffey C; Department of Biostatistics, University of Iowa, Iowa City, IA, USA., Cudkowicz M; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Durbin-Johnson B; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA, USA., Ashwood P; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA., Berry-Kravis E; Department of Pediatrics, Neurological Sciences, Anatomy, and Cell Biology, Rush University Medical Center, Chicago, IL, USA., Erickson CA; Cincinnati Hospital and Medical Center, Cincinnati, OH, USA., Filipink R; Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Gropman A; Children's National Medical Center, Washington, DC, USA., Lehwald L; Nationwide Children's Hospital, Columbus, OH, USA., Maxwell-Horn A; Vanderbilt University Medical Center, Nashville, TN, USA., Morris S; Washington University Medical Center, Saint Louis Children's Hospital, St. Louis, MO, USA., Bennett AP; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Prock L; Boston Children's Hospital, Boston, MA, USA., Talboy A; Emory University Medical Center, Atlanta, GA, USA., Tartaglia N; Children's Hospital of Colorado, Denver, CO, USA., Veenstra-VanderWeele J; Center for Autism and the Developing Brain, New York-Presbyterian, New York, NY, USA.; Department of Psychiatry, Columbia University, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Tassone F; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA.
Source: SAGE open medicine [SAGE Open Med] 2024 Sep 29; Vol. 12, pp. 20503121241282401. Date of Electronic Publication: 2024 Sep 29 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 101624744 Publication Model: eCollection Cited Medium: Print ISSN: 2050-3121 (Print) Linking ISSN: 20503121 NLM ISO Abbreviation: SAGE Open Med Subsets: PubMed not MEDLINE
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  Data: Negative effect of treatment with mGluR5 negative allosteric modulator AFQ056 on blood biomarkers in young individuals with Fragile X syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Protic+D%22">Protic D</searchLink>; Faculty of Medicine, Department of Pharmacology, Clinical Pharmacology, and Toxicology, University of Belgrade, Belgrade, Serbia.; Fragile X Clinic, Special Hospital for Cerebral Palsy and Developmental Neurology, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Breeze+E%22">Breeze E</searchLink>; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.; MIND Institute, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mendoza+G%22">Mendoza G</searchLink>; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zafarullah+M%22">Zafarullah M</searchLink>; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abbeduto+L%22">Abbeduto L</searchLink>; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hagerman+R%22">Hagerman R</searchLink>; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Pediatrics, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Coffey+C%22">Coffey C</searchLink>; Department of Biostatistics, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Cudkowicz+M%22">Cudkowicz M</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Durbin-Johnson+B%22">Durbin-Johnson B</searchLink>; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ashwood+P%22">Ashwood P</searchLink>; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Berry-Kravis+E%22">Berry-Kravis E</searchLink>; Department of Pediatrics, Neurological Sciences, Anatomy, and Cell Biology, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Erickson+CA%22">Erickson CA</searchLink>; Cincinnati Hospital and Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Filipink+R%22">Filipink R</searchLink>; Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gropman+A%22">Gropman A</searchLink>; Children's National Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Lehwald+L%22">Lehwald L</searchLink>; Nationwide Children's Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Maxwell-Horn+A%22">Maxwell-Horn A</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Morris+S%22">Morris S</searchLink>; Washington University Medical Center, Saint Louis Children's Hospital, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+AP%22">Bennett AP</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Prock+L%22">Prock L</searchLink>; Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Talboy+A%22">Talboy A</searchLink>; Emory University Medical Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tartaglia+N%22">Tartaglia N</searchLink>; Children's Hospital of Colorado, Denver, CO, USA.<br /><searchLink fieldCode="AU" term="%22Veenstra-VanderWeele+J%22">Veenstra-VanderWeele J</searchLink>; Center for Autism and the Developing Brain, New York-Presbyterian, New York, NY, USA.; Department of Psychiatry, Columbia University, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tassone+F%22">Tassone F</searchLink>; MIND Institute, University of California Davis, Sacramento, CA, USA.; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101624744%22">SAGE open medicine</searchLink> [SAGE Open Med] 2024 Sep 29; Vol. 12, pp. 20503121241282401. <i>Date of Electronic Publication: </i>2024 Sep 29 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101624744 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2050-3121 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220503121%22">20503121 </searchLink><i>NLM ISO Abbreviation: </i>SAGE Open Med <i>Subsets: </i>PubMed not MEDLINE
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